INVESTIGATING THE NEUROTOXICITY OF BISPHENOL A ON SPATIAL LEARNING AND MEMORY IN MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ASGARI HASANLUYI ELHAM; BANAN KHOJASTEH SEYED MAHDI; FAZELI MASOUMEH; HATAMI HOMEYRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2016 | Volume:26 | Issue:140 Page(s): 192-196

Download Full-Text

Persian Verion

View:

852

Download:

Cites:

Information Journal Paper

Title

INVESTIGATING THE NEUROTOXICITY OF BISPHENOL A ON SPATIAL LEARNING AND MEMORY IN MALE RATS

Author(s)

ASGARI HASANLUYI ELHAM | BANAN KHOJASTEH SEYED MAHDI | FAZELI MASOUMEH | HATAMI HOMEYRA | Issue Writer Certificate

Keywords

BISPHENOL AQ1

SPATIAL MEMORYQ2

RATQ2

Abstract

Background and purpose: BISPHENOL A is a synthetic xenoestrogen that is used in large amount to produce polymers (polycarbonates, epoxy resins). It easily cross the blood-brain barrier and is reported to influence the central nervous system especially neurogenesis and synaptic transmission. In this research the effects of chronic administration of BISPHENOL A on spatial learning and memory in adult male RATs was studied.Materials and methods: Forty male Wistar RATs were randomly divided into four groups (n=10); a control and three BPA (10 and 50 and 100 mg/kg) groups. BISPHENOL A was administered intraperitoneally for 15 days. The morris water maze was used to study the spatial learning and memory for 5 consecutive days. Data analysis was performed using one-way ANOVA.Results: Compared with the control group, treatment with BPA in 10 and 50 mg/kg doses reduced SPATIAL MEMORY (P<0.05). Reduction of SPATIAL MEMORY in the group treated with 100 mg/kg BPA was very severe compared with the control group (P<0.01).Conclusion: Results showed that BISPHENOL A increased the distance and latency time in finding the hidden platform. It seems that BISPHENOL A has negative effects on SPATIAL MEMORY by affecting synaptic transmission in central nervous system.

Cites

No record.

References

No record.

Cite

APA: Copy

ASGARI HASANLUYI, ELHAM, BANAN KHOJASTEH, SEYED MAHDI, FAZELI, MASOUMEH, & HATAMI, HOMEYRA. (2016). INVESTIGATING THE NEUROTOXICITY OF BISPHENOL A ON SPATIAL LEARNING AND MEMORY IN MALE RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(140), 192-196. SID. https://sid.ir/paper/44451/en

Vancouver: Copy

ASGARI HASANLUYI ELHAM, BANAN KHOJASTEH SEYED MAHDI, FAZELI MASOUMEH, HATAMI HOMEYRA. INVESTIGATING THE NEUROTOXICITY OF BISPHENOL A ON SPATIAL LEARNING AND MEMORY IN MALE RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(140):192-196. Available from: https://sid.ir/paper/44451/en

IEEE: Copy

ELHAM ASGARI HASANLUYI, SEYED MAHDI BANAN KHOJASTEH, MASOUMEH FAZELI, and HOMEYRA HATAMI, “INVESTIGATING THE NEUROTOXICITY OF BISPHENOL A ON SPATIAL LEARNING AND MEMORY IN MALE RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 140, pp. 192–196, 2016, [Online]. Available: https://sid.ir/paper/44451/en

Related Journal Papers