COMPARISON EFFECTS OF CLOZAPINE, ECT AND COMBINATION ECT AND CLOZAPINE ON RESISTANCE TREATMENT OF SCHIZOPHRENIA (DOUBLE BLIND)

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MASOODZADEH A.; HOSSEINI SEYED HAMZEH; RAZAGHIAN M.

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Journal: Journal of Mazandaran University of Medical Sciences Year:2006 | Volume:16 | Issue:50 Page(s): 7-14

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Title

COMPARISON EFFECTS OF CLOZAPINE, ECT AND COMBINATION ECT AND CLOZAPINE ON RESISTANCE TREATMENT OF SCHIZOPHRENIA (DOUBLE BLIND)

Author(s)

MASOODZADEH A. | HOSSEINI SEYED HAMZEH | RAZAGHIAN M. | Issue Writer Certificate

Keywords

RESISTANCE SCHIZOPHRENIAQ4

CLOZAPINEQ3

ECTQ3

COMBINATION THERAPYQ4

Abstract

Background and purpose: In spite of discovering new antipsychotics in the past years, many patients of schizophrenia don’t response to none of them and are resistance to treatment. In this case, CLOZAPINE, ECT or some combination of drug mostly be used, but there are many patients of schizophrenia who are resistance to them. In recent years, of combination of ECT and CLOZAPINE has been suggested for these patients with promising results in primary studies. The purpose of this study was to evaluate the effects of a combination of ECT CLOZAPINE in treatment of RESISTANCE SCHIZOPHRENIA in comparison with CLOZAPINE and ECT administered reparately and double blind. Materials and methods: Eighteen RESISTANCE SCHIZOPHRENIA patients were selected and divided into three groups. The first group took CLOZAPINE, the second group took ECT, and third group took a combination of ECT and CLOZAPINE. The responses to treatment evaluated with PANSS and analysed with ANOVA and t-test. Results: The rate of decrease of PANSS scale in three groups of CLOZAPINE, ECT and combination both of them were 46%, 40%, 71% respectively, with significant difference (p<0.05). Combination of ECT and CLOZAPINE showed faster response than ECT and CLOZAPINE alone. Conclusion: Combination of ECT and CLOZAPINE was effective and safe in treatment of RESISTANCE SCHIZOPHRENIA.

Cites

COMPARATIVE EVALUATION OF EDUCATIONAL-MEDICAL AND JUST MEDICAL PSYCHIATRIC WARDS IN TERMS OF DIAGNOSIS AND TREATMENT PROCESS IN SCHIZOPHRENIC PATIENTS AT RAZI PSYCHIATRIC HOSPITAL

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APA: Copy

MASOODZADEH, A., HOSSEINI, SEYED HAMZEH, & RAZAGHIAN, M.. (2006). COMPARISON EFFECTS OF CLOZAPINE, ECT AND COMBINATION ECT AND CLOZAPINE ON RESISTANCE TREATMENT OF SCHIZOPHRENIA (DOUBLE BLIND) . JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 16(50), 7-14. SID. https://sid.ir/paper/44487/en

Vancouver: Copy

MASOODZADEH A., HOSSEINI SEYED HAMZEH, RAZAGHIAN M.. COMPARISON EFFECTS OF CLOZAPINE, ECT AND COMBINATION ECT AND CLOZAPINE ON RESISTANCE TREATMENT OF SCHIZOPHRENIA (DOUBLE BLIND) . JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;16(50):7-14. Available from: https://sid.ir/paper/44487/en

IEEE: Copy

A. MASOODZADEH, SEYED HAMZEH HOSSEINI, and M. RAZAGHIAN, “COMPARISON EFFECTS OF CLOZAPINE, ECT AND COMBINATION ECT AND CLOZAPINE ON RESISTANCE TREATMENT OF SCHIZOPHRENIA (DOUBLE BLIND) ,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 50, pp. 7–14, 2006, [Online]. Available: https://sid.ir/paper/44487/en

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