INVESTIGATION OF CYTOTOXIC ACTIVITY FOR ACHILLEA TALAGONICA AND A.TENUIFOLIA

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SAEIDINIA S.; GOUHARI A.R.; GOUHARI MOHAMMAD REZA; MORADI F.; LOTFI MALDAR F.; HAJI AKHOUNDI A.

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Journal: Journal of Mazandaran University of Medical Sciences Year:2006 | Volume:16 | Issue:50 Page(s): 1-6

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Title

INVESTIGATION OF CYTOTOXIC ACTIVITY FOR ACHILLEA TALAGONICA AND A.TENUIFOLIA

Author(s)

Keywords

ACHILLEA TALAGONICAQ4

ACHILLEA TENUIFOLIAQ4

ARTEMIA SALINAQ2

CYTOTOXIC ACTIVITYQ4

Abstract

Background and purpose: Achillea (Asteraceae) comprises 115 species, which are mainly distributed in Europe, Asia, and North Africa and as introduced plant in the New World. The genus Achillea, generally named Bumadaran in Persian, is well known for medicinal properties such as anthelmintic, anti-inflammatory and anti-microbial effects. Achillea has long been used in traditional medicine for treatment of neuralgia and rheumatic pain. ACHILLEA TALAGONICA and ACHILLEA TENUIFOLIA are two of nineteen herbaceous species growing in north of Iran. In previous studies A. talagonica showed a strong in vivo immunosuppressive activity and A. tenuifolia had an antimicronial effect. Materials and methods: In this study, we examined the CYTOTOXIC ACTIVITY of the ethyl acetate, methanol and aqueous methanol extracts of the aerial parts of these two species using Brine Shrimp Cytotoxicity Assay, which is a well known screening method in order to find the active natural products using ARTEMIA SALINA eggs. Berberine hydrochloride used as a positive control (LC50=26µM). Results: The results showed that ethyl acetate and methanol extracts of both plants have a good cytotoxic effect against the larvae of A.salina. The minimum lethal concentrations of aqueous methanol extracts of them are more than 1000µM. EtOAc. Extract of A. talagonica is the most effective extract (LC50=413µM). Conclusion: EtOAc and MeOH extracts of ACHILLEA TALAGONICA and A. tenuifolia show CYTOTOXIC ACTIVITY on the active larvae of A. salina. High polarity extracts of both species showed low CYTOTOXIC ACTIVITY.

Cites

THE EFFECTS OF MILK THISTLE - EXTRACT (SILYBUM MARIAMUM) AS MEDICAL HERBAL ON NON-SPECIFIC IMMUNE SYSTEM OF RAINBOW TROUT (ONCORHYNCHUS MYKISS)

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APA: Copy

SAEIDINIA, S., GOUHARI, A.R., GOUHARI, MOHAMMAD REZA, MORADI, F., LOTFI MALDAR, F., & HAJI AKHOUNDI, A.. (2006). INVESTIGATION OF CYTOTOXIC ACTIVITY FOR ACHILLEA TALAGONICA AND A.TENUIFOLIA . JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 16(50), 1-6. SID. https://sid.ir/paper/44492/en

Vancouver: Copy

SAEIDINIA S., GOUHARI A.R., GOUHARI MOHAMMAD REZA, MORADI F., LOTFI MALDAR F., HAJI AKHOUNDI A.. INVESTIGATION OF CYTOTOXIC ACTIVITY FOR ACHILLEA TALAGONICA AND A.TENUIFOLIA . JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;16(50):1-6. Available from: https://sid.ir/paper/44492/en

IEEE: Copy

S. SAEIDINIA, A.R. GOUHARI, MOHAMMAD REZA GOUHARI, F. MORADI, F. LOTFI MALDAR, and A. HAJI AKHOUNDI, “INVESTIGATION OF CYTOTOXIC ACTIVITY FOR ACHILLEA TALAGONICA AND A.TENUIFOLIA ,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 50, pp. 1–6, 2006, [Online]. Available: https://sid.ir/paper/44492/en

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