COMPARING THE SERUM LEVELS OF 25-HYDROXYVITAMIN D AFTER TAKING INTRAVENOUS AND ORAL VITAMIN D IN PATIENTS WITH VITAMIN D INSUFFICIENCY

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MOBINI MARYAM; KASHI ZAHRA; AKHA OZRA; KHANI SOGHRA; ADELE BAHAR

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:25 | Issue:133 Page(s): 48-57

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Title

COMPARING THE SERUM LEVELS OF 25-HYDROXYVITAMIN D AFTER TAKING INTRAVENOUS AND ORAL VITAMIN D IN PATIENTS WITH VITAMIN D INSUFFICIENCY

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Keywords

VITAMIN DQ2

25 (OH) DQ2

COLECALCIFEROLQ3

ORAL ADMINISTRATIONQ2

INJECTIONSQ2

Abstract

Background and purpose: VITAMIN D is a steroid hormone which plays an important role inbone metabolism and neuromuscular function. It is mainly supplied by exposure to sunlight on the skinwith conversion of 7-dehydrocholesterol to cholecalciferol. This study aimed to compare the serum levelsof 25-hydroxyVITAMIN D after taking parenteral and oral VITAMIN D in patients with VITAMIN Dinsufficiency.Materials and methods: This historical cohort study was done among data of 400 patients withVITAMIN D insufficiency. They were treated by oral VITAMIN D3 (cholecalciferol) 50,000 IU weekly for 12weeks or intramuscular injection (IM) 300000 units weekly for two weeks. Statistical analysis wasperformed by independent and paired t-test for comparing the levels of VITAMIN D changes before andafter the treatment and between the groups.Results: The patients were 333 females (83%) and 67 males (17%). Two hundred forty twopatients received IM and 158 received oral VITAMIN D3. The mean serum levels of 25 (OH) D before andafter the intervention in oral group were 17.16±0.39 and 43.02±0.48 ng/ml (P<0.010) and in IM groupwere 17.71±0.32 and 41.72±1.20 ng/ml, respectively (P<0.001). The mean serum levels of 25 (OH) Dbefore and after the intervention were not significantly different between the two groups (P=0.48).Conclusion: Both oral and IM VITAMIN D increased 25 (OH) D levels adequately. Based onpatient’s needs and priorities, either oral or IM forms can be administered for prevention or treatment ofVITAMIN D insufficiency.

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APA: Copy

MOBINI, MARYAM, KASHI, ZAHRA, KHANI, SOGHRA, ADELE, BAHAR, & AKHA, OZRA. (2016). COMPARING THE SERUM LEVELS OF 25-HYDROXYVITAMIN D AFTER TAKING INTRAVENOUS AND ORAL VITAMIN D IN PATIENTS WITH VITAMIN D INSUFFICIENCY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 25(133), 48-57. SID. https://sid.ir/paper/44655/en

Vancouver: Copy

MOBINI MARYAM, KASHI ZAHRA, KHANI SOGHRA, ADELE BAHAR, AKHA OZRA. COMPARING THE SERUM LEVELS OF 25-HYDROXYVITAMIN D AFTER TAKING INTRAVENOUS AND ORAL VITAMIN D IN PATIENTS WITH VITAMIN D INSUFFICIENCY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;25(133):48-57. Available from: https://sid.ir/paper/44655/en

IEEE: Copy

MARYAM MOBINI, ZAHRA KASHI, SOGHRA KHANI, BAHAR ADELE, and OZRA AKHA, “COMPARING THE SERUM LEVELS OF 25-HYDROXYVITAMIN D AFTER TAKING INTRAVENOUS AND ORAL VITAMIN D IN PATIENTS WITH VITAMIN D INSUFFICIENCY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 133, pp. 48–57, 2016, [Online]. Available: https://sid.ir/paper/44655/en

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