RADIOCHEMICAL EVALUATION OF NEW 99MTC-LABELLED BOMBESIN DERIVATIVES WITH TRIPEPTIDIC (SER- SER - SER) AND (GLY-GLY-GLY) SPACER FOR TARGETING GRP RECEPTOR POSITIVE-TUMORS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SADEGHZADEH NOUROLLAH; PISHSARAIE HADI; GHASEMI YASER; EMRARIAN IMAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2015 | Volume:25 | Issue:129 Page(s): 70-80

Download Full-Text

Persian Verion

View:

662

Download:

Cites:

Information Journal Paper

Title

RADIOCHEMICAL EVALUATION OF NEW 99MTC-LABELLED BOMBESIN DERIVATIVES WITH TRIPEPTIDIC (SER- SER - SER) AND (GLY-GLY-GLY) SPACER FOR TARGETING GRP RECEPTOR POSITIVE-TUMORS

Author(s)

SADEGHZADEH NOUROLLAH | PISHSARAIE HADI | GHASEMI YASER | EMRARIAN IMAN | Issue Writer Certificate

Keywords

99MTCQ2

GRPQ2

BOMBESINQ2

RADIOPEPTIDEQ2

TUMORQ3

HYNICQ2

Abstract

Background and purpose: BOMBESIN shows very high-affinity for the Gasterin releasing peptide (GRP) receptors which are over expressed in different human TUMORs such as breast and prostate.The aim of this study was to identify a new BOMBESIN derivative labeled with 99mTc via HYNIC that might be used as a noninvasive tool for diagnosis of GRP receptor expressing TUMORs.Materials and methods: Prepared bombein derivatives were radiolabeled with 99mTc at 100oC for 10 min by exchange method and radiochemical analysis was performed using ITLC and HPLC methods. The stability of RADIOPEPTIDE was checked in the presence of human serum at 37oC and saline for up to 24 h.Results: [99mTc-EDDA/tricin/HYNIC- (Ser) 3-D-Phe13] BN (7-14) and [99mTc-EDDA/tricin/ HYNIC- (Gly) 3-D-Phe13] BN (7-14) were obtained with radiochemical purities of>95%. Results of invitro studies demonstrated a high stability in serum and saline.Conclusion: Radiolabeling of this novel conjugates with 99mTc were easily performed using exchange labeling. The prepared 99mTc-HYNIC-BN conjugates demonstrated some potential as sitedirected diagnostic radiopharmaceuticals. Therefore, more in vivo studies are required.

Cites

No record.

References

No record.

Cite

APA: Copy

SADEGHZADEH, NOUROLLAH, PISHSARAIE, HADI, GHASEMI, YASER, & EMRARIAN, IMAN. (2015). RADIOCHEMICAL EVALUATION OF NEW ^99MTC-LABELLED BOMBESIN DERIVATIVES WITH TRIPEPTIDIC (SER- SER - SER) AND (GLY-GLY-GLY) SPACER FOR TARGETING GRP RECEPTOR POSITIVE-TUMORS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 25(129), 70-80. SID. https://sid.ir/paper/44855/en

Vancouver: Copy

SADEGHZADEH NOUROLLAH, PISHSARAIE HADI, GHASEMI YASER, EMRARIAN IMAN. RADIOCHEMICAL EVALUATION OF NEW ^99MTC-LABELLED BOMBESIN DERIVATIVES WITH TRIPEPTIDIC (SER- SER - SER) AND (GLY-GLY-GLY) SPACER FOR TARGETING GRP RECEPTOR POSITIVE-TUMORS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;25(129):70-80. Available from: https://sid.ir/paper/44855/en

IEEE: Copy

NOUROLLAH SADEGHZADEH, HADI PISHSARAIE, YASER GHASEMI, and IMAN EMRARIAN, “RADIOCHEMICAL EVALUATION OF NEW ^99MTC-LABELLED BOMBESIN DERIVATIVES WITH TRIPEPTIDIC (SER- SER - SER) AND (GLY-GLY-GLY) SPACER FOR TARGETING GRP RECEPTOR POSITIVE-TUMORS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 129, pp. 70–80, 2015, [Online]. Available: https://sid.ir/paper/44855/en

Related Journal Papers