EFFECT OF GALLIC ACID ON ALKALINE PHOSPHATASE GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS

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GHANAVATI TAYEBEH; GHATREH SAMANI KEYHAN; FARROKHI EFFAT; HEYDARIAN ESFANDYAR; NIKOOKAR MORTEZA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2015 | Volume:25 | Issue:129 Page(s): 17-25

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Title

EFFECT OF GALLIC ACID ON ALKALINE PHOSPHATASE GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS

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Keywords

ATHEROSCLEROSISQ3

GALLIC ACIDQ2

ALKALINE PHOSPHATASEQ2

VASCULAR SMOOTH MUSCLE CELLSQ2

Abstract

Background and purpose: Vascular calcification is an important factor in pathogenesis of ATHEROSCLEROSIS. Studies have shown that ALKALINE PHOSPHATASE increases vascular calcification. Here we investigated the effect of GALLIC ACID on ALKALINE PHOSPHATASE gene expression in VASCULAR SMOOTH MUSCLE CELLS (VSMCs).Materials and methods: In this experimental study humans aorta VSMCs were incubated with beta glycerol phosphate as calcification-inducing media. Then these cells were treated with 160, 180 and 200 μMol concentration of GALLIC ACID for 24h, 48h and 72h. The total RNA was extracted and cDNA was synthesized and then ALKALINE PHOSPHATASE expression was measured by real time PCR. ALKALINE PHOSPHATASE specific activity was measured by spectrophotometry.Results: Overall, 160, 180 and 200 μMol concentration of GALLIC ACID decreased ALKALINE PHOSPHATASE gene expression in vascular smooth muscle cell by 1.98, 2.03, and 3.16 folds, respectively after 72h compared with the control group. The ALKALINE PHOSPHATASE specific activity also decreased compared to that of the control group.Conclusion: Our results showed that GALLIC ACID decreased the expression and activity of ALKALINE PHOSPHATASE suggesting that this antioxidant compound may attenuate vascular calcification.

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APA: Copy

GHANAVATI, TAYEBEH, GHATREH SAMANI, KEYHAN, FARROKHI, EFFAT, HEYDARIAN, ESFANDYAR, & NIKOOKAR, MORTEZA. (2015). EFFECT OF GALLIC ACID ON ALKALINE PHOSPHATASE GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 25(129), 17-25. SID. https://sid.ir/paper/44860/en

Vancouver: Copy

GHANAVATI TAYEBEH, GHATREH SAMANI KEYHAN, FARROKHI EFFAT, HEYDARIAN ESFANDYAR, NIKOOKAR MORTEZA. EFFECT OF GALLIC ACID ON ALKALINE PHOSPHATASE GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;25(129):17-25. Available from: https://sid.ir/paper/44860/en

IEEE: Copy

TAYEBEH GHANAVATI, KEYHAN GHATREH SAMANI, EFFAT FARROKHI, ESFANDYAR HEYDARIAN, and MORTEZA NIKOOKAR, “EFFECT OF GALLIC ACID ON ALKALINE PHOSPHATASE GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 129, pp. 17–25, 2015, [Online]. Available: https://sid.ir/paper/44860/en

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