EFFECT OF LAVENDER ON BLOOD BRAIN BARRIER PERMEABILITY IN RATS SUBJECTED TO ISCHEMIA

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RABIEI ZAHRA; GHOLAMI MOSTAFA; RAFIEIAN KOPAEI MAHMOUD

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Journal: Journal of Mazandaran University of Medical Sciences Year:2015 | Volume:25 | Issue:129 Page(s): 46-56

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Information Journal Paper

Title

EFFECT OF LAVENDER ON BLOOD BRAIN BARRIER PERMEABILITY IN RATS SUBJECTED TO ISCHEMIA

Author(s)

RABIEI ZAHRA | GHOLAMI MOSTAFA | RAFIEIAN KOPAEI MAHMOUD | Issue Writer Certificate

Keywords

BRAIN ISCHEMIAQ2

REPERFUSIONQ2

LAVANDULA OFFICINALISQ2

BLOOD BRAIN BARRIER PERMEABILITYQ2

Abstract

Background and purpose: Lavender is a medicinal plant with antioxidant activity. Stroke causes long term disability and is associated with oxidative stress. The present study was conducted to evaluate the protective effect of lavender extract against BLOOD BRAIN BARRIER PERMEABILITY and its possible mechanisms in an experimental model of stroke.Materials and methods: In this experimental study, 42 male Wistar rats weighing 250 to 300 g were used. The rats were divided into 6 groups (n=7 per group). Group 1 was ischemic, groups 2 and 3 were ischemic that were given 100 and 200 mg/kg lavender extract, respectively. Group 4 were intact and groups 5 and 6 were intact groups which received lavender extract with dose of 100 and 200 mg/kg.Group 7 was also considered as the sham. Focal cerebral ischemia was induced in rats by the transient occlusion of the middle cerebral artery for 1 hr. Data were analysed with SPSS and comparison of means were compared using One Way Anova.Results: The ethanolic extract of lavender at 200 mg/kg significantly reduced the BLOOD BRAIN BARRIER PERMEABILITY in rat stroke model compared with ischemic group.Conclusion: The results indicate that lavender extract has neuroprotective activity against cerebral ischemia and alleviated neurological function in rats.

Cites

Neuroprotective Effects of Stachys Lavandulifolia Hydroalcoholic Extract on Size of Cerebral Ischemia, Blood-Brain Barrier Permeability and Edema Volume in Rat Stroke Model

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APA: Copy

RABIEI, ZAHRA, GHOLAMI, MOSTAFA, & RAFIEIAN KOPAEI, MAHMOUD. (2015). EFFECT OF LAVENDER ON BLOOD BRAIN BARRIER PERMEABILITY IN RATS SUBJECTED TO ISCHEMIA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 25(129), 46-56. SID. https://sid.ir/paper/44865/en

Vancouver: Copy

RABIEI ZAHRA, GHOLAMI MOSTAFA, RAFIEIAN KOPAEI MAHMOUD. EFFECT OF LAVENDER ON BLOOD BRAIN BARRIER PERMEABILITY IN RATS SUBJECTED TO ISCHEMIA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;25(129):46-56. Available from: https://sid.ir/paper/44865/en

IEEE: Copy

ZAHRA RABIEI, MOSTAFA GHOLAMI, and MAHMOUD RAFIEIAN KOPAEI, “EFFECT OF LAVENDER ON BLOOD BRAIN BARRIER PERMEABILITY IN RATS SUBJECTED TO ISCHEMIA,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 129, pp. 46–56, 2015, [Online]. Available: https://sid.ir/paper/44865/en

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