RATE-DEPENDENT AND ANTIARRHYTHMIC REENTRANT TACHYCARDIA (AVNRT) EFFECTS OF SIMVASTATIN IN ISOLATED RABBIT ATRIOVENTRICULAR NODAL MODEL

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KHOURI V.; AMIN ALSHARIEH NAJAFI S.; ALIZADEH FATEMEH; POURABOUK M.; NAYEBPOUR M.; CHANGIZI SH.; SALEHI AREF; BADAGH ABADI F.; ALIZADEH A.M.

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2010 | Volume:20 | Issue:76 Page(s): 77-87

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Title

RATE-DEPENDENT AND ANTIARRHYTHMIC REENTRANT TACHYCARDIA (AVNRT) EFFECTS OF SIMVASTATIN IN ISOLATED RABBIT ATRIOVENTRICULAR NODAL MODEL

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Keywords

ATRIOVENTRICULAR NODEQ3

SIMVASTATINQ2

AVNRTQ3

Abstract

Background and purpose: Several previous studies have shown the direct and indirect effects of statins on supraventricular and ventricular arrhythmia. The purpose of the present study is to determine (1) whether SIMVASTATIN modifies the rate-dependent properties of the AV node, (2) to what extent such changes are related to effect of SIMVASTATIN on the basic properties of AV nodal conduction and refractoriness.Materials and methods: AV nodal refractoriness (AVERP & AVFRP) and rate dependency protocols Fatigue and Facilitation were used to assesse the electrophysiological properties of AV node.We used an isolated perfussed rabbit with AV nodal preparation in one group (N=8). The stimulation protocols were carried out during control phase and in the presence of various concentrations of SIMVASTATIN (0.5, 0.8, 1, 3, 10 mm).Results: SIMVASTATIN in concentration-dependent manner successfully prolonged effective and functional nodal refractory period (AVERP & AVFRP). Also an increase in Wenckebach cycle length was observed. SIMVASTATIN in high concentration (3, 10 mm) increases the arrhythmia threshold. Various concentrations of SIMVASTATIN increased fatigue, but it reached to significant level only at 30 mM.Conclusion: SIMVASTATIN has potential anti-AVNRT effects by elevating arrhythmia threshold and prolongation of nodal refractoriness.

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APA: Copy

KHOURI, V., AMIN ALSHARIEH NAJAFI, S., ALIZADEH, FATEMEH, POURABOUK, M., NAYEBPOUR, M., CHANGIZI, SH., SALEHI, AREF, BADAGH ABADI, F., & ALIZADEH, A.M.. (2010). RATE-DEPENDENT AND ANTIARRHYTHMIC REENTRANT TACHYCARDIA (AVNRT) EFFECTS OF SIMVASTATIN IN ISOLATED RABBIT ATRIOVENTRICULAR NODAL MODEL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 20(76), 77-87. SID. https://sid.ir/paper/44968/en

Vancouver: Copy

KHOURI V., AMIN ALSHARIEH NAJAFI S., ALIZADEH FATEMEH, POURABOUK M., NAYEBPOUR M., CHANGIZI SH., SALEHI AREF, BADAGH ABADI F., ALIZADEH A.M.. RATE-DEPENDENT AND ANTIARRHYTHMIC REENTRANT TACHYCARDIA (AVNRT) EFFECTS OF SIMVASTATIN IN ISOLATED RABBIT ATRIOVENTRICULAR NODAL MODEL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;20(76):77-87. Available from: https://sid.ir/paper/44968/en

IEEE: Copy

V. KHOURI, S. AMIN ALSHARIEH NAJAFI, FATEMEH ALIZADEH, M. POURABOUK, M. NAYEBPOUR, SH. CHANGIZI, AREF SALEHI, F. BADAGH ABADI, and A.M. ALIZADEH, “RATE-DEPENDENT AND ANTIARRHYTHMIC REENTRANT TACHYCARDIA (AVNRT) EFFECTS OF SIMVASTATIN IN ISOLATED RABBIT ATRIOVENTRICULAR NODAL MODEL,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 76, pp. 77–87, 2010, [Online]. Available: https://sid.ir/paper/44968/en

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