THERAPEUTIC EFFECTS OF TRETINOIN ON PLASMA INSULIN AND NITRIC OXIDE LEVELS IN STREPTOZOTOCIN-INDUCED DIABETES IN C57BL/6 MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MALEKIFARD FARIN; DELIREZH NOWRUZ; HOBBENAGHI RAHIM; MALEKINEJAD HASSAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2016 | Volume:26 | Issue:136 Page(s): 1-8

Download Full-Text

Persian Verion

View:

781

Download:

Cites:

Information Journal Paper

Title

THERAPEUTIC EFFECTS OF TRETINOIN ON PLASMA INSULIN AND NITRIC OXIDE LEVELS IN STREPTOZOTOCIN-INDUCED DIABETES IN C57BL/6 MICE

Author(s)

MALEKIFARD FARIN | DELIREZH NOWRUZ | HOBBENAGHI RAHIM | MALEKINEJAD HASSAN | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

TYPE 1Q3

TRETINOINQ2

NITRIC OXIDEQ2

Abstract

Background and purpose: TRETINOIN is the most active metabolite of Retinoic acid (RA) in the body. It has a variety of biological activities, including antioxidant and immunomodulatory effects on a number of inflammatory and autoimmune conditions. The purpose of this study was to investigate the effects of TRETINOIN on plasma insulin and NITRIC OXIDE levels in streptozotocin-induced diabetes in mice.Materials and methods: In this experimental study, 15 male C57BL/6 mice were divided into 3 groups (n=5 per group) including a normal group, diabetic control group (streptozotocin: 40 mg/kg/day for 5 consecutive days) and treatment group (tretinoin: 20 mg/kg/day i.p. for 21 days after induction of diabetes).Then, the levels of NITRIC OXIDE in spleen cell culture supernatant and insulin level of plasma were evaluated. Data was analyzed by One-way analysis of variance (ANOVA) and Tukey’s test in Microsoft Excel.Results: TRETINOIN prevented the STZ-induced reduction in plasma insulin, indicating a possible protective effect of TRETINOIN against b-cell damage. Also, NITRIC OXIDE production significantly reduced in treatment group (P<0.05).Conclusion: These findings indicate that TRETINOIN may have a therapeutic effect against the autoimmune destruction of the pancreatic beta-cells during the development of STZ-induced TYPE 1 diabetes in mice.

Cites

No record.

References

No record.

Cite

APA: Copy

MALEKIFARD, FARIN, DELIREZH, NOWRUZ, HOBBENAGHI, RAHIM, & MALEKINEJAD, HASSAN. (2016). THERAPEUTIC EFFECTS OF TRETINOIN ON PLASMA INSULIN AND NITRIC OXIDE LEVELS IN STREPTOZOTOCIN-INDUCED DIABETES IN C57BL/6 MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(136), 1-8. SID. https://sid.ir/paper/45000/en

Vancouver: Copy

MALEKIFARD FARIN, DELIREZH NOWRUZ, HOBBENAGHI RAHIM, MALEKINEJAD HASSAN. THERAPEUTIC EFFECTS OF TRETINOIN ON PLASMA INSULIN AND NITRIC OXIDE LEVELS IN STREPTOZOTOCIN-INDUCED DIABETES IN C57BL/6 MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(136):1-8. Available from: https://sid.ir/paper/45000/en

IEEE: Copy

FARIN MALEKIFARD, NOWRUZ DELIREZH, RAHIM HOBBENAGHI, and HASSAN MALEKINEJAD, “THERAPEUTIC EFFECTS OF TRETINOIN ON PLASMA INSULIN AND NITRIC OXIDE LEVELS IN STREPTOZOTOCIN-INDUCED DIABETES IN C57BL/6 MICE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 136, pp. 1–8, 2016, [Online]. Available: https://sid.ir/paper/45000/en

Related Journal Papers