MOLECULAR TECHNIQUES IN DETECTION OF TRIAZOLE RESISTANCE GENE MUTATIONS IN COMMON PATHOGENIC FUNGI

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KHODAVAISY SADEGH; MAHMOUDI SHAHRAM; Agha kuchak Afshari Setareh; SALEHI ZAHRA; KORD MOHAMMAD; BADALI HAMID

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Journal: Journal of Mazandaran University of Medical Sciences Year:2017 | Volume:27 | Issue:148 Page(s): 187-202

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Title

MOLECULAR TECHNIQUES IN DETECTION OF TRIAZOLE RESISTANCE GENE MUTATIONS IN COMMON PATHOGENIC FUNGI

Author(s)

Keywords

TRIAZOLE RESISTANCEQ2

MUTATIONQ3

MOLECULAR TOOLSQ1

Abstract

Invasive candidiasis and aspergillosis are amongst major medical concerns with high mortality and morbidity in immunocompromised patients. Management of these infections is dependent on early and efficient antifungal therapy, as well as drug resistance monitoring. Decreased sensitivity of these pathogens to antifungal drugs during recent decades, rapid detection of drug resistance in pathogenic fungi is highly recomended. Generally, identification of drug resistance associated MUTATIONs requires complicated and expensive methods such as DNA sequencing. However, nowadays application of accurate, fast and highly sensitive techniques, including Rolling Circle Amplification (RCA), PCR-RFLP, Real-Time PCR, and ARMS-PCR provide the possibility for detection of target sequence containing nucleotide polymorphisms even at the one base pair level. In this review we aimed to discuss the usage, advantages and disadvantages of these techniques in order to identify the MUTATIONs of the azole-resistant strains.

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APA: Copy

KHODAVAISY, SADEGH, MAHMOUDI, SHAHRAM, Agha kuchak Afshari, Setareh, SALEHI, ZAHRA, KORD, MOHAMMAD, & BADALI, HAMID. (2017). MOLECULAR TECHNIQUES IN DETECTION OF TRIAZOLE RESISTANCE GENE MUTATIONS IN COMMON PATHOGENIC FUNGI. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(148), 187-202. SID. https://sid.ir/paper/45026/en

Vancouver: Copy

KHODAVAISY SADEGH, MAHMOUDI SHAHRAM, Agha kuchak Afshari Setareh, SALEHI ZAHRA, KORD MOHAMMAD, BADALI HAMID. MOLECULAR TECHNIQUES IN DETECTION OF TRIAZOLE RESISTANCE GENE MUTATIONS IN COMMON PATHOGENIC FUNGI. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;27(148):187-202. Available from: https://sid.ir/paper/45026/en

IEEE: Copy

SADEGH KHODAVAISY, SHAHRAM MAHMOUDI, Setareh Agha kuchak Afshari, ZAHRA SALEHI, MOHAMMAD KORD, and HAMID BADALI, “MOLECULAR TECHNIQUES IN DETECTION OF TRIAZOLE RESISTANCE GENE MUTATIONS IN COMMON PATHOGENIC FUNGI,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 148, pp. 187–202, 2017, [Online]. Available: https://sid.ir/paper/45026/en

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