UPLOADING CAMEL MILK LACTOFERRIN ONTO PERFLOUROOCTYLBROMIDE NANOPARTICLES AND ITS EFFECT ON THE GROWTH OF OSTEOBLASTS CELL LINE MG-63

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SHADAN BEHNAZ; ZIBAEI SAEID; ZIA JAHROMI NOOSHA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:27 | Issue:148 Page(s): 22-31

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Title

UPLOADING CAMEL MILK LACTOFERRIN ONTO PERFLOUROOCTYLBROMIDE NANOPARTICLES AND ITS EFFECT ON THE GROWTH OF OSTEOBLASTS CELL LINE MG-63

Author(s)

SHADAN BEHNAZ | ZIBAEI SAEID | ZIA JAHROMI NOOSHA | Issue Writer Certificate

Keywords

OSTEOPORESISQ2

OSTEOBLASTQ2

LACTOFERRINQ2

NANOPARTICLESQ1

PERFLOUROOCTYL BROMIDEQ1

Abstract

Background and purpose: Osteoporosis is a common disease characterized by low bone mass that can harm health. LACTOFERRIN increase osteogenesis. PERFLOUROOCTYL BROMIDE is a neutral particle that used as a drug carier.Materials and methods: In this study, LACTOFERRIN (LF) of Camel milk were isolated. PFOB-NEP was prepared using an oil-in-water emulsion method (O/W). and then evaluated by The zeta potential measurement methods and tryptophan fluorescence spectroscopy before and after loaded by LACTOFERRIN. The concentrations of 25, 50 and 100 mg/mL of LF were loaded on perflourooctylbromide -NEPs. The effects of standard LF, the LF, and LF loaded on PFOB-NEPs on growth of OSTEOBLASTs Cell Line (MG-63) was studied using MTT assay.Results: The results showed that the LF and the LF loaded on PFOB-NEPs significantly increased OSTEOBLAST cells proliferation. But there was no significant difference between the LF and LF uploaded on PFOB-NEPs (a<1%). But there were significant differences of growth in different concentrations of lactoferrin relative to each other in both LACTOFERRIN and LACTOFERRIN loaded on NANOPARTICLES (α<5%).Conclusion: The results proved that LF of camel milk causes the growth of OSTEOBLASTs cells in MG-63 cell lines. It is also possible to load LF on PFOB-NEPs and this nanoparticle could be used as carriers of LACTOFERRIN.

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APA: Copy

SHADAN, BEHNAZ, ZIBAEI, SAEID, & ZIA JAHROMI, NOOSHA. (2017). UPLOADING CAMEL MILK LACTOFERRIN ONTO PERFLOUROOCTYLBROMIDE NANOPARTICLES AND ITS EFFECT ON THE GROWTH OF OSTEOBLASTS CELL LINE MG-63. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(148), 22-31. SID. https://sid.ir/paper/45028/en

Vancouver: Copy

SHADAN BEHNAZ, ZIBAEI SAEID, ZIA JAHROMI NOOSHA. UPLOADING CAMEL MILK LACTOFERRIN ONTO PERFLOUROOCTYLBROMIDE NANOPARTICLES AND ITS EFFECT ON THE GROWTH OF OSTEOBLASTS CELL LINE MG-63. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;27(148):22-31. Available from: https://sid.ir/paper/45028/en

IEEE: Copy

BEHNAZ SHADAN, SAEID ZIBAEI, and NOOSHA ZIA JAHROMI, “UPLOADING CAMEL MILK LACTOFERRIN ONTO PERFLOUROOCTYLBROMIDE NANOPARTICLES AND ITS EFFECT ON THE GROWTH OF OSTEOBLASTS CELL LINE MG-63,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 148, pp. 22–31, 2017, [Online]. Available: https://sid.ir/paper/45028/en

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