EFFECT OF ANDROGRAPHOLIDE ON PARAOXONASE 2 EXPRESSION IN MALE WISTAR RATS

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ALIPANAH MOGHADAM REZA; MEHRI ARASH; NAGHIZADEH BAGHI ABBAS; NEMATI ALI; MALEKZADEH VADOUD; MAZANI MOHAMMAD; MANAFI FARIDEH; Mohammadzadeh Vardin Mohammad; MOHAMMADNIA ALIREZA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:160 Page(s): 1-7

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Title

EFFECT OF ANDROGRAPHOLIDE ON PARAOXONASE 2 EXPRESSION IN MALE WISTAR RATS

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Keywords

PARAOXONASE 2Q1

WISTAR RATQ2

ANDROGRAPHOLIDEQ1

Abstract

Background and purpose: The PARAOXONASE 2 is one of the paraoxonase family enzymes, which, unlike the paraoxonase 1 and 3, is an intracellular antioxidant system expressed in many cells. Andrographophyllide is a plant that has recently received attention and is used in many fields due todifferent properties, including antioxidant property. The purpose of this study was to evaluate the effect ofandrographolide on PARAOXONASE 2 expression. Materials and methods: In this study, 18 WISTAR RATs were divided into three groups, includinga control group (receiving physiologic serum) and two experimental groups that received 3. 5 mg/kgandrographolide and 7 mg/kg ANDROGRAPHOLIDE. Real-time PCR was performed to evaluate the expressionof PARAOXONASE 2. Results: Compared to the control group, ANDROGRAPHOLIDE at 3. 5 and 7 mg/kg body weightreduced the liver expression of PARAOXONASE 2. The rate of expression of PARAOXONASE 2 was somewhatsimilar in both doses. Conclusion: To the best of our knowledge, for the first time, current study showed that injectionof ANDROGRAPHOLIDE extract at 3. 5 and 7mg/kg body weight of male rats reduced the expression of liverPARAOXONASE 2.

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APA: Copy

ALIPANAH MOGHADAM, REZA, MEHRI, ARASH, NAGHIZADEH BAGHI, ABBAS, NEMATI, ALI, MALEKZADEH, VADOUD, MAZANI, MOHAMMAD, MANAFI, FARIDEH, Mohammadzadeh Vardin, Mohammad, & MOHAMMADNIA, ALIREZA. (2018). EFFECT OF ANDROGRAPHOLIDE ON PARAOXONASE 2 EXPRESSION IN MALE WISTAR RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(160 ), 1-7. SID. https://sid.ir/paper/45199/en

Vancouver: Copy

ALIPANAH MOGHADAM REZA, MEHRI ARASH, NAGHIZADEH BAGHI ABBAS, NEMATI ALI, MALEKZADEH VADOUD, MAZANI MOHAMMAD, MANAFI FARIDEH, Mohammadzadeh Vardin Mohammad, MOHAMMADNIA ALIREZA. EFFECT OF ANDROGRAPHOLIDE ON PARAOXONASE 2 EXPRESSION IN MALE WISTAR RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(160 ):1-7. Available from: https://sid.ir/paper/45199/en

IEEE: Copy

REZA ALIPANAH MOGHADAM, ARASH MEHRI, ABBAS NAGHIZADEH BAGHI, ALI NEMATI, VADOUD MALEKZADEH, MOHAMMAD MAZANI, FARIDEH MANAFI, Mohammad Mohammadzadeh Vardin, and ALIREZA MOHAMMADNIA, “EFFECT OF ANDROGRAPHOLIDE ON PARAOXONASE 2 EXPRESSION IN MALE WISTAR RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 160 , pp. 1–7, 2018, [Online]. Available: https://sid.ir/paper/45199/en

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