BRIEF REPORT: INHIBITORY EFFECT OF IBUPROFEN ON ANGIOGENESIS IN GASTRIC CANCER STEM CELLS

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MAHMOUDI FATEMEH; AKRAMI HASSAN

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:26 | Issue:143 Page(s): 224-229

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Title

BRIEF REPORT: INHIBITORY EFFECT OF IBUPROFEN ON ANGIOGENESIS IN GASTRIC CANCER STEM CELLS

Author(s)

MAHMOUDI FATEMEH | AKRAMI HASSAN | Issue Writer Certificate

Keywords

IBUPROFENQ2

ANGIOGENESISQ2

GASTRIC CANCER STEM CELLSQ1

Abstract

Background and purpose: ANGIOGENESIS provides proper nutrition and helps to the development and spread of cancer cells. Cancer stem cells are a rare population of tumor cells responsible for initiation, spreading and growth of cancer. ANGIOGENESIS occurs more in cancer stem cells compared with other cancer cells. IBUPROFEN, as a member of nonsteroidal anti-inflammatory drugs (NSAIDs) group is used for prevention and treatment of certain cancers. In the present study, we investigated the effect of IBUPROFEN on ANGIOGENESIS in GASTRIC CANCER STEM CELLS.Materials and methods: GASTRIC CANCER STEM CELLS of MKN45 cell line was isolated by spheroid colony formation technique. GASTRIC CANCER STEM CELLS were treated with various concentrations of IBUPROFEN. The angiogenic properties in GASTRIC CANCER STEM CELLS treated with IBUPROFEN was compared with control cells using two-dimensional ANGIOGENESIS.Results: ANGIOGENESIS reduced in the cancer stem cells treated with IBUPROFEN compared with the control cancer stem cells.Conclusion: IBUPROFEN decreased ANGIOGENESIS in GASTRIC CANCER STEM CELLS.

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APA: Copy

MAHMOUDI, FATEMEH, & AKRAMI, HASSAN. (2016). BRIEF REPORT: INHIBITORY EFFECT OF IBUPROFEN ON ANGIOGENESIS IN GASTRIC CANCER STEM CELLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(143), 224-229. SID. https://sid.ir/paper/45241/en

Vancouver: Copy

MAHMOUDI FATEMEH, AKRAMI HASSAN. BRIEF REPORT: INHIBITORY EFFECT OF IBUPROFEN ON ANGIOGENESIS IN GASTRIC CANCER STEM CELLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(143):224-229. Available from: https://sid.ir/paper/45241/en

IEEE: Copy

FATEMEH MAHMOUDI, and HASSAN AKRAMI, “BRIEF REPORT: INHIBITORY EFFECT OF IBUPROFEN ON ANGIOGENESIS IN GASTRIC CANCER STEM CELLS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 143, pp. 224–229, 2016, [Online]. Available: https://sid.ir/paper/45241/en

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