IN VIVO PROTECTIVE EFFECT OF MYRICETIN ON LIVER BIOCHEMICAL DAMAGE INDUCED BY ENDOSULFAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHOKRZADEH MOHAMMAD; EBRAHIMNEJAD HANIEH; ZEAR ALI; CHABRA AROONA; NAGHSHVAR FARSHAD; AHMADI AMIRHOSSEIN

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:26 | Issue:143 Page(s): 28-36

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

653

Download:

Cites:

Information Journal Paper

Title

IN VIVO PROTECTIVE EFFECT OF MYRICETIN ON LIVER BIOCHEMICAL DAMAGE INDUCED BY ENDOSULFAN

Author(s)

Keywords

ENDOSULFANQ2

ANTIOXIDANTSQ1

GLUTATHIONEQ3

LIVERQ2

Abstract

Background and purpose: ENDOSULFAN is an organochlorine insecticide that is absorbed orally, subcutaneously and by inhalation in humans and animals and disturbs the reduction process, changes the activity of antioxidant enzymes and increases the lipid peroxidation in many organs. The aim of this study was to evaluate the protective effect of myricetin against ENDOSULFAN induced LIVER damage.Materials and methods: In an experimental study 42 male Wister rats were randomly divided into 7 groups (n=6 per group). GroupI served as the control and the experimental groups were as follows: groupII- Ѵ received ENDOSULFAN 10 mg/kg and myricetin 5, 10, 15, and 20 mg/kg/ip for 30 days, respectively. GroupѴI was treated only by 10 mg/kg ENDOSULFAN and group ѴII as positive control received 10 mg/kg cyclophosphamide (ip, 30 days). Twenty four hours after the last injection, all rats were anesthetized using ethyl ether. Alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and superoxide dismutase (SOD) levels were measured in plasma. LIVER GLUTATHIONE (GSH) levels were also determined.Results: Administration of ENDOSULFAN caused elevation in ALT, AST, ALP and SOD levels, but the activity of GSH decreased in LIVER tissue. Receiving myricetin along with ENDOSULFAN significantly increased body antioxidant activity and normalized the LIVERenzyme levels (P˂ 0.05).Conclusion: Our results indicated that myricetin with antioxidant effect could protect cells against harmful free radicals. Therefore, further clinical trials are suggested.

Cites

No record.

References

No record.

Cite

APA: Copy

SHOKRZADEH, MOHAMMAD, EBRAHIMNEJAD, HANIEH, ZEAR, ALI, CHABRA, AROONA, NAGHSHVAR, FARSHAD, & AHMADI, AMIRHOSSEIN. (2016). IN VIVO PROTECTIVE EFFECT OF MYRICETIN ON LIVER BIOCHEMICAL DAMAGE INDUCED BY ENDOSULFAN. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(143), 28-36. SID. https://sid.ir/paper/45253/en

Vancouver: Copy

SHOKRZADEH MOHAMMAD, EBRAHIMNEJAD HANIEH, ZEAR ALI, CHABRA AROONA, NAGHSHVAR FARSHAD, AHMADI AMIRHOSSEIN. IN VIVO PROTECTIVE EFFECT OF MYRICETIN ON LIVER BIOCHEMICAL DAMAGE INDUCED BY ENDOSULFAN. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(143):28-36. Available from: https://sid.ir/paper/45253/en

IEEE: Copy

MOHAMMAD SHOKRZADEH, HANIEH EBRAHIMNEJAD, ALI ZEAR, AROONA CHABRA, FARSHAD NAGHSHVAR, and AMIRHOSSEIN AHMADI, “IN VIVO PROTECTIVE EFFECT OF MYRICETIN ON LIVER BIOCHEMICAL DAMAGE INDUCED BY ENDOSULFAN,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 143, pp. 28–36, 2016, [Online]. Available: https://sid.ir/paper/45253/en

Related Journal Papers