COMPARING ENDOTHELIN A RECEPTOR EXPRESSION IN DYSPLASIA AND ORAL SQUAMOUS CELL CARCINOMA

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RAJABI MOGHADDAM MAHDIEH; ABBASZADEH HAMID; GHOLINIA HEMMAT

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Title

COMPARING ENDOTHELIN A RECEPTOR EXPRESSION IN DYSPLASIA AND ORAL SQUAMOUS CELL CARCINOMA

Author(s)

RAJABI MOGHADDAM MAHDIEH | ABBASZADEH HAMID | GHOLINIA HEMMAT | Issue Writer Certificate

Keywords

SQUAMOUS CELL CARCINOMAQ2

DYSPLASIAQ3

ENDOTHELIN A RECEPTORQ1

Abstract

Background and purpose: Endothelin axis (endothelin or ET) including ENDOTHELIN A RECEPTOR(ETA) play a major role as the regulator of vessels tone and tissue differentiation and development. Thereare evidences of the importance of endothelin axis in carcinogenesis. No data exists about comparison ofETA expression between DYSPLASIA and oral SQUAMOUS CELL CARCINOMA (OSCC). So, the aim of this studywas to compare immunohistochemical expression of ETA between these two groups. Materials and methods: In this cross-sectional study, the paraffin-embedded tissue blocks of20 cases of dysplastic oral mucosa and 21 cases of OSCCs were investigated. Three micron sections wereprepared from tissue blocks and stained with ETA antibody using immunohistochemistry. Percentage ofstained cells and staining intensity were compared between the groups applying Mann-Whitney and Chi-Square tests. Results: In DYSPLASIA group, 11 cases stained for ETA while in OSCC group all cases stained. Comparison of percentage of stained cells and their semi quantitative classification showed significantdifferences between the two groups (P=0. 02 and P=0. 005, respectively) such that ETA expression washigher in OSCC than DYSPLASIA. Staining intensity for ETA was significantly higher in OSCC group(P=0. 006). There were significant differences between ETA expression in mild and moderate DYSPLASIAwith carcinoma. Conclusion: Our results support the role of ETA receptor in progression of DYSPLASIA toward OSCC.

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APA: Copy

RAJABI MOGHADDAM, MAHDIEH, ABBASZADEH, HAMID, & GHOLINIA, HEMMAT. (2018). COMPARING ENDOTHELIN A RECEPTOR EXPRESSION IN DYSPLASIA AND ORAL SQUAMOUS CELL CARCINOMA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(165 ), 47-56. SID. https://sid.ir/paper/45363/en

Vancouver: Copy

RAJABI MOGHADDAM MAHDIEH, ABBASZADEH HAMID, GHOLINIA HEMMAT. COMPARING ENDOTHELIN A RECEPTOR EXPRESSION IN DYSPLASIA AND ORAL SQUAMOUS CELL CARCINOMA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(165 ):47-56. Available from: https://sid.ir/paper/45363/en

IEEE: Copy

MAHDIEH RAJABI MOGHADDAM, HAMID ABBASZADEH, and HEMMAT GHOLINIA, “COMPARING ENDOTHELIN A RECEPTOR EXPRESSION IN DYSPLASIA AND ORAL SQUAMOUS CELL CARCINOMA,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 165 , pp. 47–56, 2018, [Online]. Available: https://sid.ir/paper/45363/en

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