Brain Structural Changes Caused by Autism Spectrum Disorder Based on Volumetric Analysis of Magnetic Resonance Images: A Review Study

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Sanati Shiva; Saadatmand Mahdi; NEKOOEI SIROUS

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Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:29 | Issue:171 Page(s): 130-144

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Information Journal Paper

Title

Brain Structural Changes Caused by Autism Spectrum Disorder Based on Volumetric Analysis of Magnetic Resonance Images: A Review Study

Author(s)

Sanati Shiva | Saadatmand Mahdi | NEKOOEI SIROUS | Issue Writer Certificate

Keywords

autism spectrum disorderQ1

magnetic resonance imagingQ1

brain volume measurementQ1

early diagnosisQ1

Abstract

Background and purpose: autism spectrum disorder (ASD) is a psychiatric disorder which occurs in early years of life and causes various individual and social problems. Early detection of autism would help in taking necessary precautions and preventing its adverse side effects. Methods & Materials: In this paper, we reviewed the articles that have investigated brain structural changes caused by ASD based on brain volumetric analysis in magnetic resonance images. We studied 37 papers about brain volume measurement, 34 articles concerning brain structural changes in autistic patients, 9 about brain functional changes, and 15 on major causes, diagnosis, and treatment of autism. Results: According to literature, autism leads to whole brain enlargement (1. 58%-10%). ASD was reported to cause increase in the volume of left anterior temporal gyrus, left posterior cingulate gyrus, right calcarine sulcus, left and right lingual gyrus, left precuneus, and right thalamus. But, no considerable volume changes were detected in the white matter. Also, autistic patients were found to have lower activity in the fusiform gyrus and broca region compared to normal subjects. Conclusion: Brain structural analysis using magnetic resonance imaging provides promising evidences for early detection of autism in children younger than three years of age. However, to evaluate brain structural changes in autistic patients, considering the theory of age-specific anatomic abnormalities (brain enlargement in childhood and brain volume decrease in adulthood), gender, and intelligence quotient are necessary.

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APA: Copy

Sanati, Shiva, Saadatmand, Mahdi, & NEKOOEI, SIROUS. (2019). Brain Structural Changes Caused by Autism Spectrum Disorder Based on Volumetric Analysis of Magnetic Resonance Images: A Review Study. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(171 ), 130-144. SID. https://sid.ir/paper/45482/en

Vancouver: Copy

Sanati Shiva, Saadatmand Mahdi, NEKOOEI SIROUS. Brain Structural Changes Caused by Autism Spectrum Disorder Based on Volumetric Analysis of Magnetic Resonance Images: A Review Study. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;29(171 ):130-144. Available from: https://sid.ir/paper/45482/en

IEEE: Copy

Shiva Sanati, Mahdi Saadatmand, and SIROUS NEKOOEI, “Brain Structural Changes Caused by Autism Spectrum Disorder Based on Volumetric Analysis of Magnetic Resonance Images: A Review Study,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 171 , pp. 130–144, 2019, [Online]. Available: https://sid.ir/paper/45482/en

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