Protective Effect of Zataria Multiflora Boiss against Cisplatin-Induced Hematotoxicity in Mice

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KARIMI SHOKOOH; HOSSEINIMEHR SEYED JALAL; KARIMPOUR MALEKSHAH ABBASALI; TALEBPOUR AMIRI FERESHTEH

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Journal: Journal of Mazandaran University of Medical Sciences Year:2019 | Volume:29 | Issue:171 Page(s): 92-98

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Title

Protective Effect of Zataria Multiflora Boiss against Cisplatin-Induced Hematotoxicity in Mice

Author(s)

KARIMI SHOKOOH | HOSSEINIMEHR SEYED JALAL | KARIMPOUR MALEKSHAH ABBASALI | TALEBPOUR AMIRI FERESHTEH | Issue Writer Certificate

Keywords

CisplatinQ2

Zataria Multiflora BoissQ3

hematological parametersQ2

Abstract

Background and purpose: Cisplatin (CP) is an anticancer drug that cause hematological changes. Zataria Multiflora Boiss (ZM) has antioxidant property. The preset study was done to determine the protective effect of ZM against hematological changes induced by Cisplatin in mice. Materials and methods: Thirty two adult male mice (25-30 g) were divided into 4 groups: the control group received normal saline for 7 days; ZM group received ZM (200 mg/kg) for 7 days by gavage; CP group received Intraperitoneal CP (10 mg/kg) injection at day 5; ZM + CP group received ZM for 7 days and CP was injected at day 5. Then, blood samples were taken for hematological assessment at day 8 of the study. Data were analyzed by SPSS applying ANOVA and Tukey test. Results: The number of red blood cells, hemoglobin levels, platelets, MCV, MCH, and MCHC significantly decreased and white blood cells increased in the group that received CP compared with those of the control group. ZM improved these changes (P<0. 05). Conclusion: ZM improved hematological changes induced by Cisplatin in mice.

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APA: Copy

KARIMI, SHOKOOH, HOSSEINIMEHR, SEYED JALAL, KARIMPOUR MALEKSHAH, ABBASALI, & TALEBPOUR AMIRI, FERESHTEH. (2019). Protective Effect of Zataria Multiflora Boiss against Cisplatin-Induced Hematotoxicity in Mice. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(171 ), 92-98. SID. https://sid.ir/paper/45487/en

Vancouver: Copy

KARIMI SHOKOOH, HOSSEINIMEHR SEYED JALAL, KARIMPOUR MALEKSHAH ABBASALI, TALEBPOUR AMIRI FERESHTEH. Protective Effect of Zataria Multiflora Boiss against Cisplatin-Induced Hematotoxicity in Mice. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;29(171 ):92-98. Available from: https://sid.ir/paper/45487/en

IEEE: Copy

SHOKOOH KARIMI, SEYED JALAL HOSSEINIMEHR, ABBASALI KARIMPOUR MALEKSHAH, and FERESHTEH TALEBPOUR AMIRI, “Protective Effect of Zataria Multiflora Boiss against Cisplatin-Induced Hematotoxicity in Mice,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 171 , pp. 92–98, 2019, [Online]. Available: https://sid.ir/paper/45487/en

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