PROTECTIVE EFFECTS OF SCF IN INHIBITING X-RAY INDUCED APOPTOSIS IN HL60 CELLS

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HOSSEINIMEHR S.J.; MAHMOUDZADEH AZIZ; AKHLAGHPOUR SH.

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2006 | Volume:16 | Issue:51 Page(s): 18-23

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Title

PROTECTIVE EFFECTS OF SCF IN INHIBITING X-RAY INDUCED APOPTOSIS IN HL60 CELLS

Author(s)

HOSSEINIMEHR S.J. | MAHMOUDZADEH AZIZ | AKHLAGHPOUR SH. | Issue Writer Certificate

Keywords

APOPTOSISQ2

CYTOKINEQ3

SCFQ3

IRRADIATIONQ3

Abstract

Background and purpose: APOPTOSIS or programmed cell death is a process of cell suicide. Ionizing radiation is one of the stimuli for APOPTOSIS, acting through DNA damage. In the present study, effects of x-rays induced APOPTOSIS in HL60 cells, as well as the protective effects of SCF (Stem Cell Factor) in inhibiting x-ray induced APOPTOSIS have been evaluated.Materials and methods: Exposure of HL60 cells to 5 Gy of X-ray and the time effect on the percentage of apoptotic cells has been studied. One group of cells were incubated with SCF in the growth medium at 37 o C for 1 h before X-ray. Other groups of cells were incubated with SCF and MAPK, PI3K and PKC inhibitors as the cellular pathway proteins, and the x-ray induced APOPTOSIS was studied.Results: Results of the X-ray induced APOPTOSIS showed a graduall increase from 12h to 60h after X-ray. The SCF attenuated the percentage of apoptotic cells when cells were treated with SCF 1 h before X-ray. X-rays induced APOPTOSIS partially attenuated by a combination treatment of SCF, PKC and PI3K inhibitor, but it was not inhibited by the SCF and ERK inhibitors.Conclusion: Our results have shown that SCF activated MAPK pathway proteins and this activated pathway leads to cell survival and resistance against side effects induced by X-ray in HL60. SCF protected cells against X-rays through the activation of MAPK pathway.

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APA: Copy

HOSSEINIMEHR, S.J., MAHMOUDZADEH, AZIZ, & AKHLAGHPOUR, SH.. (2006). PROTECTIVE EFFECTS OF SCF IN INHIBITING X-RAY INDUCED APOPTOSIS IN HL60 CELLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 16(51), 18-23. SID. https://sid.ir/paper/45532/en

Vancouver: Copy

HOSSEINIMEHR S.J., MAHMOUDZADEH AZIZ, AKHLAGHPOUR SH.. PROTECTIVE EFFECTS OF SCF IN INHIBITING X-RAY INDUCED APOPTOSIS IN HL60 CELLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;16(51):18-23. Available from: https://sid.ir/paper/45532/en

IEEE: Copy

S.J. HOSSEINIMEHR, AZIZ MAHMOUDZADEH, and SH. AKHLAGHPOUR, “PROTECTIVE EFFECTS OF SCF IN INHIBITING X-RAY INDUCED APOPTOSIS IN HL60 CELLS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 51, pp. 18–23, 2006, [Online]. Available: https://sid.ir/paper/45532/en

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