AN OVERVIEW OF ANTICANCER CHALCONES WITH APOPTOSIS INDUCING ACTIVITY

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MIRZAEI HASSAN; KEIGHOBADI MASOUD; EMAMI SAEED

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Journal: Journal of Mazandaran University of Medical Sciences Year:2017 | Volume:26 | Issue:146 Page(s): 254-268

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Information Journal Paper

Title

AN OVERVIEW OF ANTICANCER CHALCONES WITH APOPTOSIS INDUCING ACTIVITY

Author(s)

MIRZAEI HASSAN | KEIGHOBADI MASOUD | EMAMI SAEED | Issue Writer Certificate

Keywords

CANCERQ2

ANTICANCER AGENTSQ1

APOPTOSISQ1

CHALCONESQ1

DRUG DISCOVERYQ1

Abstract

CANCER is a complex and life-threatening disease involving uncontrollable cell proliferation, evading APOPTOSIS, and metastasis. Despite recent developments in CANCER chemotherapy, there are no effective broad spectrum antiCANCER agents that could selectively target CANCER cells. Thus, designing and discovering new efficient and selective antiCANCER agents are urgent needs. It is important that new antiCANCER agents could act via APOPTOSIS induction, since it has a critical role in control of cell proliferation. CHALCONES are naturally occurring compounds possessing high degree of synthetic diversity for design of new leading bioactive compounds including antiCANCER agents. CHALCONES are considered as promising antiCANCER agents against most human CANCERs with capability of inducing APOPTOSIS in CANCER cells. Furthermore, some clinically useful antiCANCER drugs show genotoxicity due to interaction with DNA, but CHALCONES with different mechanism may be devoid of this side effect. This review highlights the recently identified antiCANCER CHALCONES from naturally or synthetically origins that induce APOPTOSIS in CANCER cells. The diversity of scaffolds described in this review along with their structure-activity relationships could help medicinal chemists in development of new selective antiCANCER CHALCONES with improved potency.

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APA: Copy

MIRZAEI, HASSAN, KEIGHOBADI, MASOUD, & EMAMI, SAEED. (2017). AN OVERVIEW OF ANTICANCER CHALCONES WITH APOPTOSIS INDUCING ACTIVITY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(146), 254-268. SID. https://sid.ir/paper/45563/en

Vancouver: Copy

MIRZAEI HASSAN, KEIGHOBADI MASOUD, EMAMI SAEED. AN OVERVIEW OF ANTICANCER CHALCONES WITH APOPTOSIS INDUCING ACTIVITY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;26(146):254-268. Available from: https://sid.ir/paper/45563/en

IEEE: Copy

HASSAN MIRZAEI, MASOUD KEIGHOBADI, and SAEED EMAMI, “AN OVERVIEW OF ANTICANCER CHALCONES WITH APOPTOSIS INDUCING ACTIVITY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 146, pp. 254–268, 2017, [Online]. Available: https://sid.ir/paper/45563/en

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