EVALUATION OF RELATION BETWEEN IL-4 AND IFN- γ POLYMORPHISMS AND TYPE 2 DIABETES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DANESHMANDI S.; POURFATH ELAH A.A.; KAZEMI ARABABADI M.; HASANSHAHI GH.H.; REZAEIAN MOHSEN; ASIABANHA REZAEI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:18 | Issue:66 Page(s): 35-41

Download Full-Text

Persian Verion

View:

853

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF RELATION BETWEEN IL-4 AND IFN- γ POLYMORPHISMS AND TYPE 2 DIABETES

Author(s)

Keywords

IL-4Q3

IFN-γ POLYMORPHISMQ3

TYPE 2 DIABETESQ3

Abstract

Background and purpose: Although TYPE 2 DIABETES is the most frequent among different types of diabetes, the cause of it is yet to be clarified. Several environmental and genetic factors are said to be involved in diabetes and it has been established that cytokines play key roles in pathogenesis of diabetes. Expression of cytokines is different from person and in deferent societies. Studies showed that polymorphisms of +874 of IFN-g and -590 of IL-4 regions are related to the expression of these genes. In this study, we aimed to find polymorphisms of these regions in TYPE 2 DIABETES patients.Material and methods: In this study peripheral blood samples were collected from 51 TYPE 2 DIABETES patients and 50 healthy controls. DNA was isolated by salting out method, using ARMS-PCR, RFLP-PCR polymorphisms of = 874 of IFN-g and -590 of IL-4, were analyzed, respectively.Results: Our findings showed that TT genotype of IFN- g was increased in type 2 diabetic patients as comford with control group but difference was not significant. Our results also have not shown any significant difference between IL-4 genotype in diabetic and healthy controls.Discussion: Our results suggested that TT genotype of IFN- g can be related to diabetes. This relation can be sescribed by this known Todgment judyunt thar over expression of IFN- g shifted immune system to Th1, therefore, pancreas cells were miscarried by immune cells.

Cites

EVALUATION OF RELATION BETWEEN IL-4 AND IFN-γ: POLYMORPHISMS AND TYPE 2 DIABETES

References

No record.

Cite

APA: Copy

DANESHMANDI, S., POURFATH ELAH, A.A., KAZEMI ARABABADI, M., HASANSHAHI, GH.H., REZAEIAN, MOHSEN, & ASIABANHA REZAEI, M.. (2008). EVALUATION OF RELATION BETWEEN IL-4 AND IFN- γ POLYMORPHISMS AND TYPE 2 DIABETES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 18(66), 35-41. SID. https://sid.ir/paper/45647/en

Vancouver: Copy

DANESHMANDI S., POURFATH ELAH A.A., KAZEMI ARABABADI M., HASANSHAHI GH.H., REZAEIAN MOHSEN, ASIABANHA REZAEI M.. EVALUATION OF RELATION BETWEEN IL-4 AND IFN- γ POLYMORPHISMS AND TYPE 2 DIABETES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;18(66):35-41. Available from: https://sid.ir/paper/45647/en

IEEE: Copy

S. DANESHMANDI, A.A. POURFATH ELAH, M. KAZEMI ARABABADI, GH.H. HASANSHAHI, MOHSEN REZAEIAN, and M. ASIABANHA REZAEI, “EVALUATION OF RELATION BETWEEN IL-4 AND IFN- γ POLYMORPHISMS AND TYPE 2 DIABETES,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 66, pp. 35–41, 2008, [Online]. Available: https://sid.ir/paper/45647/en

Related Journal Papers