EFFECT OF ROYAL JELLY ON PERIPHERAL BLOOD MONONUCLEAR CELLS CYTOTOXICITY AGAINST THE K562 ERYTHROLEUKEMIA CELL LINE

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HOSSEINI SEYED EHSAN; DELEREZH NOROUZ; AFZAL AHANGARAN NAHID

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2014 | Volume:24 | Issue:114 Page(s): 1-7

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Title

EFFECT OF ROYAL JELLY ON PERIPHERAL BLOOD MONONUCLEAR CELLS CYTOTOXICITY AGAINST THE K562 ERYTHROLEUKEMIA CELL LINE

Author(s)

HOSSEINI SEYED EHSAN | DELEREZH NOROUZ | AFZAL AHANGARAN NAHID | Issue Writer Certificate

Keywords

ROYAL JELLYQ2

K562Q2

PERIPHERAL BLOOD MONONUCLEAR CELLQ1

Abstract

Background and purpose: ROYAL JELLY (RJ) is a substance synthesized by worker bee- is shown to have various biological activities on different cells and tissues of the human body. In this study the effect of RJ on PERIPHERAL BLOOD MONONUCLEAR CELLs cytotoxicity against the K562 Erythroleukemia cell line was investigated.Material and methods: In this experimental study human PBMCs (106 cells/ml) were separately cultured in standard conditions. The cells were then incubated with different concentrations of RJ (5 mg/ml, 10 mg/ml, 25 mg/ml) for 72 hours. Subsequently, cytotoxic effect of PBMCs pulsed with RJ on K562 was evaluated by Anexin PI test (Flow cytometry).Results: In the Anexin PI test, apoptotic property and cytotoxic effect of PBMCs pulsed with RJ on K562 increased significantly compared to those of the control group.Conclusion: PBMCs pulsed with RJ increased survival rate of PBMCs after treatment with RJ. This compound could be beneficial in preventing and controlling carcinoma cells.

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APA: Copy

HOSSEINI, SEYED EHSAN, DELEREZH, NOROUZ, & AFZAL AHANGARAN, NAHID. (2014). EFFECT OF ROYAL JELLY ON PERIPHERAL BLOOD MONONUCLEAR CELLS CYTOTOXICITY AGAINST THE K562 ERYTHROLEUKEMIA CELL LINE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 24(114), 1-7. SID. https://sid.ir/paper/45743/en

Vancouver: Copy

HOSSEINI SEYED EHSAN, DELEREZH NOROUZ, AFZAL AHANGARAN NAHID. EFFECT OF ROYAL JELLY ON PERIPHERAL BLOOD MONONUCLEAR CELLS CYTOTOXICITY AGAINST THE K562 ERYTHROLEUKEMIA CELL LINE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;24(114):1-7. Available from: https://sid.ir/paper/45743/en

IEEE: Copy

SEYED EHSAN HOSSEINI, NOROUZ DELEREZH, and NAHID AFZAL AHANGARAN, “EFFECT OF ROYAL JELLY ON PERIPHERAL BLOOD MONONUCLEAR CELLS CYTOTOXICITY AGAINST THE K562 ERYTHROLEUKEMIA CELL LINE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 114, pp. 1–7, 2014, [Online]. Available: https://sid.ir/paper/45743/en

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