COMPARING CLOBAZAM WITH DIAZEPAM IN PREVENTING FEBRILE SEIZURE IN CHILDREN: A RANDOMIZED CLINICAL TRIAL

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AMOUIAN SEPIDEH; JALILI AKBARIAN MAHDI; ARABI MOHSEN

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2014 | Volume:24 | Issue:111 Page(s): 23-32

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Title

COMPARING CLOBAZAM WITH DIAZEPAM IN PREVENTING FEBRILE SEIZURE IN CHILDREN: A RANDOMIZED CLINICAL TRIAL

Author(s)

AMOUIAN SEPIDEH | JALILI AKBARIAN MAHDI | ARABI MOHSEN | Issue Writer Certificate

Keywords

FEVERQ3

SEIZUREQ3

DIAZEPAMQ2

RECURRENCEQ2

CLOBAZAMQ2

Abstract

Background and purpose: Febrile SEIZURE is a SEIZURE associated with FEVER without any evidence of intracranial infection or electrolytic disorder. Its treatment includes anticonvulsant medicines administered for preventing RECURRENCE. In this research, treatments with DIAZEPAM and CLOBAZAM were evaluated in preventing febrile SEIZURE RECURRENCE among patients admitted to Taleghani Hospital.Material and Methods: The study population included 150 patients with simple febrile SEIZURE aged between six months to six years of old. They were randomly assigned into two groups to receive either DIAZEPAM or CLOBAZAM after control of SEIZURE. The patients received DIAZEPAM 0.33 mg/kg/ dose every 8h and CLOBAZAM in 2.5, 5, 7.5, and 10 mg/kg every 12 h. The results involving FEVER episodes in each 3 months, side effects of medicines and RECURRENCE were recorded in a check list and then analyzed.Results: Among the patients 32 were excluded and 118 patients including 61 in DIAZEPAM group and 57 in CLOBAZAM group were studied. There were 62 males and 56 females in this population. The mean age was 21.05±10.10 months and 21.96±10.74 months in DIAZEPAM and CLOBAZAM groups, respectively and 21.49±10.39 in total population. There was no significant difference between the two groups in RECURRENCE of febrile SEIZURE (P>0.05). No significant difference was found in incidence of ataxia between the two groups. In the group receiving DIAZEPAM 45.9% of the patients had drowsiness compared to 8.8% in clobazm group (P>0.05). No significant difference was found between the studied groups for medicinal side effects including ataxia, vomiting, anorexia, and irritability (P>0.05).Conclusion: Treatment by CLOBAZAM caused RECURRENCE and complications less than DIAZEPAM. However, more studies including larger sample sizes are required to confirm these results.

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APA: Copy

AMOUIAN, SEPIDEH, JALILI AKBARIAN, MAHDI, & ARABI, MOHSEN. (2014). COMPARING CLOBAZAM WITH DIAZEPAM IN PREVENTING FEBRILE SEIZURE IN CHILDREN: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 24(111), 23-32. SID. https://sid.ir/paper/45810/en

Vancouver: Copy

AMOUIAN SEPIDEH, JALILI AKBARIAN MAHDI, ARABI MOHSEN. COMPARING CLOBAZAM WITH DIAZEPAM IN PREVENTING FEBRILE SEIZURE IN CHILDREN: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;24(111):23-32. Available from: https://sid.ir/paper/45810/en

IEEE: Copy

SEPIDEH AMOUIAN, MAHDI JALILI AKBARIAN, and MOHSEN ARABI, “COMPARING CLOBAZAM WITH DIAZEPAM IN PREVENTING FEBRILE SEIZURE IN CHILDREN: A RANDOMIZED CLINICAL TRIAL,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 111, pp. 23–32, 2014, [Online]. Available: https://sid.ir/paper/45810/en

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