THE ROLE OF NA+-K+ -ATPASE RATE DEPENDENT PROPERTIES OF EHANOLIC EXTRACT OF URTICA DIOICA ROOT ON ISOLATED RABBIT AV-NODAL PREPARATION

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KHOURI V.; NAYEBPOUR M.; MIRABBASI A.; AZADBAKHT M.; SALEHI AREF

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Journal: Journal of Mazandaran University of Medical Sciences Year:2008 | Volume:17 | Issue:61 Page(s): 20-29

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Title

THE ROLE OF NA+-K+ -ATPASE RATE DEPENDENT PROPERTIES OF EHANOLIC EXTRACT OF URTICA DIOICA ROOT ON ISOLATED RABBIT AV-NODAL PREPARATION

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Keywords

FUNCTIONAL PROPERTIESQ3

AV-NODEQ3

ARRHYTHMIAQ3

URTICA DIOICA ROOTQ3

Abstract

Background and Purpose: Previous studies have demonstrated the cardiovascular effects of Urtica dioica (Nettle) such as anti-hypertensive, and negative inotropic effects on heart. The effects of plant on atrioventricular node have not been explored yet. Inhibitory Na+-K+-ATPas pump has been shown ny U. dioica. The aims of the present study were:1) to determine concentration-dependent effects of ethanolic extract of nettle on the nodal basic and FUNCTIONAL PROPERTIES.2) to compare mechanism of action nettel with ouabaine and verapamil. Materials and Methods: This was an experimental study. Male New Zealand rabbits (1-1.3 kg) were used in all of the experiments; Various experimental stimulating protocols (Wbc1; Recovery, Facilitation, Fatigue) were applied to assess electrophysiological properties of Node. We used isolated perfused AV-nodal preparation (n=18). All protocols were repeated in the presence and absence (control) of different concentration (0.2-0.4 g/l) of Nettle, verapamil (0.1 mM) and ouabaine (0.25 mM). Results were shown as Mean±SE and a probability of 5% was used to indicate statistical significance.Results: In the presence of Nettel, significant increases in WBCL (150.7±4.3 to 180±15.2 msec), AVCT (44±2.5 to 54±1.7msec), ERP (125±13 to 149±20.6msec) and magnitude of fatigue (D.AH) 6±0.9 msec were observed. The nettel has less inhibitory activity than verapamil, such as ERP of Nettel was 40% ofverapamil. Also, Nettel had similar electrophysiological effects in regard to ouabain.Conclusion: In the present study, negative donnotropic effect of extract, Citrus bigaradia of Nettel, was observed on the isolated AV-nodal preparation. The same electrophysiological trend of ouabain and Nettel, may indicate the role of Na+-K+-ATPas pump in the depressant effect of Nettel.

Cites

STUDY THE EFFECTS OF URTICA DIOICA EXTRACT ON HISTOMORPHOMETRICAL STRUCTURE OF RAT SCIATIC NERVE FOLLOWING EXPERIMENTAL DIABETES

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APA: Copy

KHOURI, V., NAYEBPOUR, M., MIRABBASI, A., AZADBAKHT, M., & SALEHI, AREF. (2008). THE ROLE OF NA⁺-K⁺ -ATPASE RATE DEPENDENT PROPERTIES OF EHANOLIC EXTRACT OF URTICA DIOICA ROOT ON ISOLATED RABBIT AV-NODAL PREPARATION. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 17(61), 20-29. SID. https://sid.ir/paper/45900/en

Vancouver: Copy

KHOURI V., NAYEBPOUR M., MIRABBASI A., AZADBAKHT M., SALEHI AREF. THE ROLE OF NA⁺-K⁺ -ATPASE RATE DEPENDENT PROPERTIES OF EHANOLIC EXTRACT OF URTICA DIOICA ROOT ON ISOLATED RABBIT AV-NODAL PREPARATION. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;17(61):20-29. Available from: https://sid.ir/paper/45900/en

IEEE: Copy

V. KHOURI, M. NAYEBPOUR, A. MIRABBASI, M. AZADBAKHT, and AREF SALEHI, “THE ROLE OF NA⁺-K⁺ -ATPASE RATE DEPENDENT PROPERTIES OF EHANOLIC EXTRACT OF URTICA DIOICA ROOT ON ISOLATED RABBIT AV-NODAL PREPARATION,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 61, pp. 20–29, 2008, [Online]. Available: https://sid.ir/paper/45900/en

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