SIDE EFFECTS OF CLOZAPINE IN TREATMENT - RESISTANT SCHIZOPHRENIC PATIENTS

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MIRABZADEH A.; FARHADY Y.; FADAEE F.; KARIMI MORTEZA; BARATI SADEH F.

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2006 | Volume:16 | Issue:52 Page(s): 39-47

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Title

SIDE EFFECTS OF CLOZAPINE IN TREATMENT - RESISTANT SCHIZOPHRENIC PATIENTS

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Keywords

CLOZAPINEQ3

SIDE EFFECTSQ3

SCHIZOPHRENIAQ3

TREATMENT-RESISTANTQ2

Abstract

Background and purpose: CLOZAPINE is an atypical antipsychotic with the least extrapyramidal SIDE EFFECTS and more agranulositosis than typical antipsychotics. CLOZAPINE has the unique effects on the TREATMENT-RESISTANT SCHIZOPHRENIA but with threatening SIDE EFFECTS on the patients. Thus we did this prospective study in order to identufy the SIDE EFFECTS of CLOZAPINE in Iranian TREATMENT-RESISTANT schizopherenic patients at Razi psychiatric center, Iran.Materials and methods: We selected 80 TREATMENT-RESISTANT schizopherenic patients on the basis of DSM-IV. After 2 weeks drug free period, the aptients received Haloperidol for 6 weeks and then 40 patients were selected with BPRS score above 45. These patients took CLOZAPINE with the similar way which increased to 900 mg/day. They were assessed by internal SIDE EFFECTS, EPS questionnaires and laboratory examination weekly followed for 20 weeks.Results: The results showed that 8 patients were excluded from study due to severe SIDE EFFECTS. The most prevalent internal SIDE EFFECTS were fatigue and sedation and were siallorrhea the most prevalent extrapyramidal symptom. The difference between the mean of WBC, RBC and hemoglobin and the score of EPS in the early and late stages of treatment were not significant statistically, but significant for platelet.Conclusion: Careful clinical monitoring of the physical status and specially hematological status during treatment with CLOZAPINE and education to the patients and their care givers carers can prevent fatality by early recognition of severe SIDE EFFECTS.

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APA: Copy

MIRABZADEH, A., FARHADY, Y., FADAEE, F., KARIMI, MORTEZA, & BARATI SADEH, F.. (2006). SIDE EFFECTS OF CLOZAPINE IN TREATMENT - RESISTANT SCHIZOPHRENIC PATIENTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 16(52), 39-47. SID. https://sid.ir/paper/46017/en

Vancouver: Copy

MIRABZADEH A., FARHADY Y., FADAEE F., KARIMI MORTEZA, BARATI SADEH F.. SIDE EFFECTS OF CLOZAPINE IN TREATMENT - RESISTANT SCHIZOPHRENIC PATIENTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;16(52):39-47. Available from: https://sid.ir/paper/46017/en

IEEE: Copy

A. MIRABZADEH, Y. FARHADY, F. FADAEE, MORTEZA KARIMI, and F. BARATI SADEH, “SIDE EFFECTS OF CLOZAPINE IN TREATMENT - RESISTANT SCHIZOPHRENIC PATIENTS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 52, pp. 39–47, 2006, [Online]. Available: https://sid.ir/paper/46017/en

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