EFFECT OF GLYCERIN ON INDOMETHACIN RELEASE PROFILE FROM THEIR LIQUISOLID COMPACTS

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SAEIDI MAJID; AKBARI J.; ENAYATIFARD R.; SARRESHTEHDAR SH.

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Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2009 | Volume:19 | Issue:69 Page(s): 53-61

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Title

EFFECT OF GLYCERIN ON INDOMETHACIN RELEASE PROFILE FROM THEIR LIQUISOLID COMPACTS

Author(s)

SAEIDI MAJID | AKBARI J. | ENAYATIFARD R. | SARRESHTEHDAR SH. | Issue Writer Certificate

Keywords

INDOMETHACINQ3

LIQUISOLIDQ3

GLYCERINQ3

AVICELQ3

DISSOLUTIONQ3

DSCQ2

Abstract

Background and purpose: The increasing effect of LIQUISOLID systems on DISSOLUTION behavior of poor soluble drugs has been proved. In this research, the effect of GLYCERIN, as a nonvolatile solvent, on release profile of INDOMETHACIN was evaluated.Materials and methods: The AVICEL as carrier and silica as coating powder material in 20: 1 ratio were used. INDOMETHACIN was dispersed in GLYCERIN with different ratios. The binary mixtures of AVICEL and silica were added to the mixture containing the drug and GLYCERIN under continuous mixing. Starch as disintegrate was mixed with all formulations for a period of 10 minutes. After preparing several formulations, the release profiles were evaluated. To evaluate any interaction between INDOMETHACIN and the other components in LIQUISOLID formulations, the differential scanning calorimeter (DSC) was used.Results: The results showed that LIQUISOLID formulations exhibited significantly higher drug DISSOLUTION rates in comparison with directly compressed tablet. The enhanced rate of INDOMETHACIN DISSOLUTION from LIQUISOLID tablets was probably due to an increase in wetting properties and surface area of drug particles available for DISSOLUTION. Also, it has been shown that the fraction of molecularly dispersed drug (FM) in the liquid medication of LIQUISOLID systems was directly proportional to their INDOMETHACIN DISSOLUTION rate (DR). An attempt was made to correlate the percentage drug dissolved in 10-minutes with the solubility of INDOMETHACIN in GLYCERIN.Conclusion: The LIQUISOLID compacts technique can be a promising alternative for the formulation of water insoluble drugs, such as INDOMETHACIN into rapid release tablets.

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APA: Copy

SAEIDI, MAJID, ENAYATIFARD, R., AKBARI, J., & SARRESHTEHDAR, SH.. (2009). EFFECT OF GLYCERIN ON INDOMETHACIN RELEASE PROFILE FROM THEIR LIQUISOLID COMPACTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 19(69), 53-61. SID. https://sid.ir/paper/46135/en

Vancouver: Copy

SAEIDI MAJID, ENAYATIFARD R., AKBARI J., SARRESHTEHDAR SH.. EFFECT OF GLYCERIN ON INDOMETHACIN RELEASE PROFILE FROM THEIR LIQUISOLID COMPACTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;19(69):53-61. Available from: https://sid.ir/paper/46135/en

IEEE: Copy

MAJID SAEIDI, R. ENAYATIFARD, J. AKBARI, and SH. SARRESHTEHDAR, “EFFECT OF GLYCERIN ON INDOMETHACIN RELEASE PROFILE FROM THEIR LIQUISOLID COMPACTS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 69, pp. 53–61, 2009, [Online]. Available: https://sid.ir/paper/46135/en

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