HISTOPATHOLOGICAL STUDY OF DI-(2-ETHYLHEXYL) PHTHALATE (DEHP) ON TESTES IN MOUSE

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ZARE Z.; IMANI H.; MOHAMMADI MOSLEM; MOFID MAHMOUD; DASHTNAVARD H.

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Journal: Journal of Mazandaran University of Medical Sciences Year:2009 | Volume:19 | Issue:71 Page(s): 52-59

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Title

HISTOPATHOLOGICAL STUDY OF DI-(2-ETHYLHEXYL) PHTHALATE (DEHP) ON TESTES IN MOUSE

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Keywords

HISTOPATHOLOGICAL STUDYQ2

DI-(2-ETHYLHEXYL) PHTHALATEQ3

TESTISQ2

SERTOLI CELLQ3

Abstract

Background and purpose: Di-(2-ethylhexyl) phthalate (DEHP) is plasticizer used commonly in a variety of polyvinyl chloride- based consumable products. The purpose of this study was to evaluate the effects of DEHP on body weight, TESTIS weight, seminiferous tubular diameter, seminiferous epithelium height, seminiferous lumen diameter, number of SERTOLI CELLs and round spermatids per seminiferous tubule in mice. Materials and methods: The protocol for DEHP administration was that adult male NMRI mice (the age group of 4 weeks) received 2g DEHP/100ml corn oil/kg, and vehicle group received 100 ml corn oil/ kg by gavage for 14 days. The control group did not receive DEHP. All animals were weighed on the first and terminal day of the experiment. The left and right without fat TESTIS, weights were recorded for each animal. Left TESTIS was fixed in Bouinś solution, routinely processed for embedding in paraffin and staining of 5 mm sections with hematoxilin and eosin (H&E) for histopathological examination. Results: Administration of DEHP induced the reduction of body and TESTIS weight significantly (p<0.05). Furthermore, DEHP decreased the seminiferous tubular diameter, seminiferous epithelium height, and seminiferous lumen diameter. The number of SERTOLI CELLs and round spermatids in seminiferous tubule was significantly low, compared with control group. Conclusion: These results demonstrated that DEHP administration has toxicant effects on body and TESTIS weight, spermatogenesis process, along with male reproductive system.

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APA: Copy

ZARE, Z., IMANI, H., MOHAMMADI, MOSLEM, MOFID, MAHMOUD, & DASHTNAVARD, H.. (2009). HISTOPATHOLOGICAL STUDY OF DI-(2-ETHYLHEXYL) PHTHALATE (DEHP) ON TESTES IN MOUSE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 19(71), 52-59. SID. https://sid.ir/paper/46166/en

Vancouver: Copy

ZARE Z., IMANI H., MOHAMMADI MOSLEM, MOFID MAHMOUD, DASHTNAVARD H.. HISTOPATHOLOGICAL STUDY OF DI-(2-ETHYLHEXYL) PHTHALATE (DEHP) ON TESTES IN MOUSE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;19(71):52-59. Available from: https://sid.ir/paper/46166/en

IEEE: Copy

Z. ZARE, H. IMANI, MOSLEM MOHAMMADI, MAHMOUD MOFID, and H. DASHTNAVARD, “HISTOPATHOLOGICAL STUDY OF DI-(2-ETHYLHEXYL) PHTHALATE (DEHP) ON TESTES IN MOUSE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 71, pp. 52–59, 2009, [Online]. Available: https://sid.ir/paper/46166/en

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