BACTERIAL ETIOLOGY AND ANTIBIOTIC RESISTANCE OF NEONOTAL SEPSIS

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MOZAFAR N.A.; ASGHARI F.; HOSSEINI S.Z.A.D.

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Journal Paper

Paper Information

Journal: Medical Journal of Tabriz University of Medical Sciences Year:2006 | Volume:27 | Issue:4 Page(s): 107-110

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Title

BACTERIAL ETIOLOGY AND ANTIBIOTIC RESISTANCE OF NEONOTAL SEPSIS

Author(s)

MOZAFAR N.A. | ASGHARI F. | HOSSEINI S.Z.A.D. | Issue Writer Certificate

Keywords

SEPSISQ4

NEONATEQ2

ANTIMICROBIOL RESISTANCEQ2

PREMATURE NEONATEQ2

Abstract

Background and objectives: Early and late SEPSIS in newborns is common causes of early deaths or long-lasting disabilities in infants. They have varied etiologies and death rates.In this survey, the bacterial etiologic agents for neonatal SEPSIS cases and their antibiotic sensitivity patterns were determined.Materials and Methods: during 2003-2004, blood samples were collected and processed by culture from 198 newborns who were clinically diagnosed with early SEPSIS in Western Mazandaran area hospitals. Subsequent to bacterial isolation and identification, disk diffusion antibiotic susceptibility testings were performed according to the NCCLS guidelines.Results: The study population was 69.7% boys and 38% of them were born with normal vaginal delivery with the rest being C-section delivered babies. The patient risk factors included premature delivery, very low birth weight (<1.5 kg) and Hyaline membrane disease (HMD). The average age of the studied population was 10.53±1.48 days old and the mean length of therapy was 9 days. 63% of these NEONATEs were infected by early SEPSIS and 37% were infected by late SEPSIS. The highest death rates (45%) were associated with the very low birth weights. Coagulase negative Staphylococci (34,5%) and Klebsiella pneumoniae (17.2%) comprised the most isolated bacteria. The Gram positive isolates showed the highest sensitivity and resistance rates to vancomycin (96%) and to cloxacillin (65.5%) respectively.The highest sensitivity and resistance rates for the Gram negative isolates were towards ciprofloxacin (95%) and cephaloth in (94%), respectively.Conclusion: The prevalence of early SEPSIS rates were higher in the boy infants and also in those delivered by C-section operation. The highest risk factor was pre-mature delivery. The high prevalence of antibiotic resistance rates in the isolated bacteria was the major cause of failed therapy and deaths. Adequate pregnancy care in order to reduce pre-mature labor, with considering hygienic principles in hospitals, late SEPSIS can be avoided and prompt antibiogram tests are measures necessary to reduce morbidity and mortality of early SEPSIS.

Cites

STUDY OF THE ROLE OF COMMON BACTERIAL ETIOLOGY IN NEONATAL SEPSIS IN URUMIAH SHAHID AREFIAN HOSPITAL

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APA: Copy

MOZAFAR, N.A., ASGHARI, F., & HOSSEINI, S.Z.A.D.. (2006). BACTERIAL ETIOLOGY AND ANTIBIOTIC RESISTANCE OF NEONOTAL SEPSIS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 27(4), 107-110. SID. https://sid.ir/paper/46637/en

Vancouver: Copy

MOZAFAR N.A., ASGHARI F., HOSSEINI S.Z.A.D.. BACTERIAL ETIOLOGY AND ANTIBIOTIC RESISTANCE OF NEONOTAL SEPSIS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;27(4):107-110. Available from: https://sid.ir/paper/46637/en

IEEE: Copy

N.A. MOZAFAR, F. ASGHARI, and S.Z.A.D. HOSSEINI, “BACTERIAL ETIOLOGY AND ANTIBIOTIC RESISTANCE OF NEONOTAL SEPSIS,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 4, pp. 107–110, 2006, [Online]. Available: https://sid.ir/paper/46637/en

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