EVALUATION OF THE EFFECT OF INTRAPERITONEAL AND INTRACEREBROVENTRICULAR INJECTION OF VITAMIN B6 ON POSITIVE REINFORCING EFFECT OF MORPHINE IN CONDITIONED PLACE PREFERENCE (CPP) MODEL IN MALE RAT

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ABBASI MALEKI SAEID; NOURI MOHAMMAD; ESKANDARY HADI; ABBASI MALEKI NAVID; CHERAGHYAN SYAMAK

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2012 | Volume:33 | Issue:5 Page(s): 85-90

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Title

EVALUATION OF THE EFFECT OF INTRAPERITONEAL AND INTRACEREBROVENTRICULAR INJECTION OF VITAMIN B6 ON POSITIVE REINFORCING EFFECT OF MORPHINE IN CONDITIONED PLACE PREFERENCE (CPP) MODEL IN MALE RAT

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Keywords

VITAMIN B6Q3

MORPHINEQ2

GABAQ2

CONDITIONED PLACE PREFERENCEQ2

CONDITIONED PLACE AVERSIONQ2

Abstract

Background and Objectives: GABAergic system in ventral tegmental area (VTA) and nucleus accumbens (NAc) plays critical role in opiate reinforcement. On the other hand, VITAMIN B6 has a role in formation of different neurotransmitters such as GABA. The aim of this study was to investigate the effect of intraperitoneal (ip) and intracerebroventricular (icv) injection of VITAMIN B6 on positive reinforcing effect of MORPHINE in male rat. Materials and Methods: Ninety male rats were divided into treatment and control groups (15×6). This experimental study took place on six consecutive days, which consisted of three distinct phases: preconditioning, conditioning and postconditioning. For intracerebroventricular study, a sterile guide cannula was stereotaxically placed in left ventricle. After conditioning by MORPHINE (5mg/kg, ip), on day 6 different doses of VITAMIN B6 were injected intrapertioneally (5, 15 and 40 mg/kg) and intracerebroventriculary (5 and 10µg/rat). Control groups received saline instead these drugs.Results: Intraperitoneal injection (ip) of different doses of MORPHINE induced CPP (P<0.001). Intraperitoneal injection of different doses of VITAMIN B6 alone did not induce any significant CPP or CPA. But, co-administration of VITAMIN B6 and MORPHINE, significantly induced CPA (P<0.05) and this effect potentiated in icv injection in dose dependent maneuver manner (P<0.05 and P<0.01, respectively).Conclusion: It seems that VITAMIN B6 reduce MORPHINE reinforcement through affecting GABAergic VTA neurons and subsequent decrease in NAc dopamine release. Therefore, it can be candidate for control or treatment of MORPHINE craving and relapse in their dependent subjects.

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APA: Copy

ABBASI MALEKI, SAEID, NOURI, MOHAMMAD, ESKANDARY, HADI, ABBASI MALEKI, NAVID, & CHERAGHYAN, SYAMAK. (2012). EVALUATION OF THE EFFECT OF INTRAPERITONEAL AND INTRACEREBROVENTRICULAR INJECTION OF VITAMIN B6 ON POSITIVE REINFORCING EFFECT OF MORPHINE IN CONDITIONED PLACE PREFERENCE (CPP) MODEL IN MALE RAT. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 33(5), 85-90. SID. https://sid.ir/paper/46718/en

Vancouver: Copy

ABBASI MALEKI SAEID, NOURI MOHAMMAD, ESKANDARY HADI, ABBASI MALEKI NAVID, CHERAGHYAN SYAMAK. EVALUATION OF THE EFFECT OF INTRAPERITONEAL AND INTRACEREBROVENTRICULAR INJECTION OF VITAMIN B6 ON POSITIVE REINFORCING EFFECT OF MORPHINE IN CONDITIONED PLACE PREFERENCE (CPP) MODEL IN MALE RAT. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;33(5):85-90. Available from: https://sid.ir/paper/46718/en

IEEE: Copy

SAEID ABBASI MALEKI, MOHAMMAD NOURI, HADI ESKANDARY, NAVID ABBASI MALEKI, and SYAMAK CHERAGHYAN, “EVALUATION OF THE EFFECT OF INTRAPERITONEAL AND INTRACEREBROVENTRICULAR INJECTION OF VITAMIN B6 ON POSITIVE REINFORCING EFFECT OF MORPHINE IN CONDITIONED PLACE PREFERENCE (CPP) MODEL IN MALE RAT,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 33, no. 5, pp. 85–90, 2012, [Online]. Available: https://sid.ir/paper/46718/en

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