BLASTS IN PERIPHERAL BLOOD SAMPLE OF PATIENTS WITH ACUTE LEUKEMIA; A COMPARATIVE STUDY BY H1 AND FLOW CYTOMETRY

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MALJAEI S.H.; VAEZ GHARAMALEKI J.

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2007 | Volume:28 | Issue:4 Page(s): 109-113

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Title

BLASTS IN PERIPHERAL BLOOD SAMPLE OF PATIENTS WITH ACUTE LEUKEMIA; A COMPARATIVE STUDY BY H1 AND FLOW CYTOMETRY

Author(s)

MALJAEI S.H. | VAEZ GHARAMALEKI J. | Issue Writer Certificate

Keywords

LEUKEMIAQ3

BLASTQ3

H1Q3

FLOW CYTOMETRYQ3

Abstract

Background and Objectives: BLAST in peripheral blood and bone marrow is a diagnostic factor in acute LEUKEMIA. the percentage of BLASTs will be also important in patient management, particularly after chemotropy. Although conventional study of the cells by light microscopy is an essential step, however, it is time consuming and the obtained results may vary from one to other. The H1 system that not only able to automatically differentiate all blood leukocytes, it is also calculate the percentage of BLAST cells. To evaluate the accuracy of results by the H1 on BLAST, the study was set to investigate that issus in comparison by CD45 dimly expressed cells (blasts) that computed by FLOW CYTOMETRY.Materials and Methods: Blood samples from 17 patients with acute lymphoid LEUKEMIA (ALL) and 31 patients with acute myeloid LEUKEMIA (AML) simultaneously were studied by H1 and FLOW CYTOMETRY using anti-CD45 and CD45/RALS gating. Blood samples from 50 patients with chronic lymphocyte LEUKEMIA (CLL) were used as negative controls.Results: The mean values of H1-blasts for B-ALL, T-ALL and AML were 16.3%, 27% and 49.6%, respectively. These figures were 66.6%, 79.7% and 87% by FLOW CYTOMETRY. Both systems were not identified any BLAST in CLL cases.Conclusion: Analysis of blood samples by H1 in cases with CLL is trusty, but in cases with acute LEUKEMIA is unreliable. In comparison to flow cytometr, H1 is identified significantly (p<0.05) lower number of BLAST in acute LEUKEMIA.

Cites

EVALUTION OF IMMUNOPHENOTYPE IN CHILDREN WITH ACUT LYMPHOBLASTIC LEUKEMIA ADMITTED TO SHAHID SADOUGHI HOSPITAL, YAZD

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APA: Copy

MALJAEI, S.H., & VAEZ GHARAMALEKI, J.. (2007). BLASTS IN PERIPHERAL BLOOD SAMPLE OF PATIENTS WITH ACUTE LEUKEMIA; A COMPARATIVE STUDY BY H1 AND FLOW CYTOMETRY. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 28(4), 109-113. SID. https://sid.ir/paper/46908/en

Vancouver: Copy

MALJAEI S.H., VAEZ GHARAMALEKI J.. BLASTS IN PERIPHERAL BLOOD SAMPLE OF PATIENTS WITH ACUTE LEUKEMIA; A COMPARATIVE STUDY BY H1 AND FLOW CYTOMETRY. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;28(4):109-113. Available from: https://sid.ir/paper/46908/en

IEEE: Copy

S.H. MALJAEI, and J. VAEZ GHARAMALEKI, “BLASTS IN PERIPHERAL BLOOD SAMPLE OF PATIENTS WITH ACUTE LEUKEMIA; A COMPARATIVE STUDY BY H1 AND FLOW CYTOMETRY,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 4, pp. 109–113, 2007, [Online]. Available: https://sid.ir/paper/46908/en

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