THERAPEUTIC AND PROPHYLACTIC EFFECTS OF CHRONIC CEREBROLYSIN REGIMEN ON THE MOTOR DISORDERS OF HYPERGLYCEMIC RATS

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VAHIDI EYRISOFLA NAZILA; Yazdian Mohammad Reza; MAHMOUDI JAVAD

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2017 | Volume:39 | Issue:2 Page(s): 77-84

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Title

THERAPEUTIC AND PROPHYLACTIC EFFECTS OF CHRONIC CEREBROLYSIN REGIMEN ON THE MOTOR DISORDERS OF HYPERGLYCEMIC RATS

Author(s)

VAHIDI EYRISOFLA NAZILA | Yazdian Mohammad Reza | MAHMOUDI JAVAD | Issue Writer Certificate

Keywords

CEREBROLYSINQ1

DIABETESQ2

HYPERGLYCEMIAQ1

RATQ2

Abstract

Background: Diabetic HYPERGLYCEMIA is one of the complication of DIABETES leads to development of motor neurons and movement dysfunction. In this study, using open field test, the effect of CEREBROLYSIN, as a compound with several neurotrophic factors, has evaluated on the HYPERGLYCEMIA induced locomotor disorders. Methods: Following induction of DIABETES, motor behavior of RATs was assessed on days 7, 14 and 21, post DIABETES induction. Results showed that on day 21, animals developed marked locomotion impairments. Diabetic animals were divided in to pretreatment and treatment groups. In both groups CEREBROLYSIN was injected intraperitoneally for 21 consecutive days. Animal in pretreatment groups received different doses of CEREBROLYSIN (1, 2. 5 and 5 ml/kg). In treatment groups CEREBROLYSIN was injected at the doses of 5 ml/kg. Results: Results from open field test in diabetic RATs showed that, long-term administration of CEREBROLYSIN only at the dose of 5 ml/kg improves motor disorders both in pretreatment (P<0. 01) and treatment groups (P<0. 05). Conclusions: According to obtained results, it seems that CEREBROLYSIN can exhibit prophylactic and have therapeutic effects against the HYPERGLYCEMIA induced locomotor complications in diabetic RATs.

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APA: Copy

VAHIDI EYRISOFLA, NAZILA, Yazdian, Mohammad Reza, & MAHMOUDI, JAVAD. (2017). THERAPEUTIC AND PROPHYLACTIC EFFECTS OF CHRONIC CEREBROLYSIN REGIMEN ON THE MOTOR DISORDERS OF HYPERGLYCEMIC RATS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 39(2 ), 77-84. SID. https://sid.ir/paper/46974/en

Vancouver: Copy

VAHIDI EYRISOFLA NAZILA, Yazdian Mohammad Reza, MAHMOUDI JAVAD. THERAPEUTIC AND PROPHYLACTIC EFFECTS OF CHRONIC CEREBROLYSIN REGIMEN ON THE MOTOR DISORDERS OF HYPERGLYCEMIC RATS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;39(2 ):77-84. Available from: https://sid.ir/paper/46974/en

IEEE: Copy

NAZILA VAHIDI EYRISOFLA, Mohammad Reza Yazdian, and JAVAD MAHMOUDI, “THERAPEUTIC AND PROPHYLACTIC EFFECTS OF CHRONIC CEREBROLYSIN REGIMEN ON THE MOTOR DISORDERS OF HYPERGLYCEMIC RATS,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 39, no. 2 , pp. 77–84, 2017, [Online]. Available: https://sid.ir/paper/46974/en

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