THE STUDY OF ACUTE PHASE PROTEINS IN PATIENTS SUFFERING FROM ACUTE VIRAL HEPATITIS

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ABOU ALFATHI A.A.; MOHSENEI MOVAHHED A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2000 | Volume:34 | Issue:46 Page(s): 3-10

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Title

THE STUDY OF ACUTE PHASE PROTEINS IN PATIENTS SUFFERING FROM ACUTE VIRAL HEPATITIS

Author(s)

ABOU ALFATHI A.A. | MOHSENEI MOVAHHED A. | Issue Writer Certificate

Keywords

ACUTE VIRAL HEPATITISQ3

HBS AG ++Q4

HBS AG - ACUTE PHASE PROTEINSQ4

Abstract

Following an acute phase stimulus, such as inflammation many liver-derived plasma proteins are changed in concentration .In order to study the serum concentration of acute phase proteins in ACUTE VIRAL HEPATITIS CRP , Alpha-1- Antitrypsin (AAT), Alpha-I-Acid Glycoprotein(AAG) ,Haptoglobin, Transferrin, Ceruloplasmin, the third component of complement (C3) and the plasma concentration of fibrinogen were measured in patients suffering from ACUTE VIRAL HEPATITIS .The samples were obtained from 60 ACUTE VIRAL HEPATITIS patients; including 37 males and 23 females at the age between 3-45 in two groups of 21 HBS Ag+ patients and 39 HBs Ag - patients. The patients samples were compared with 60 healthy subjects who were similar to the sample group with respect to age and sex. The serum total protein and albumin didn't change significantly compared with control group (p>0.05).The pattern of hepatic enzymes changes in patients was identical to ACUTE VIRAL HEPATITIS. It was observed that in both groups of patients there were increases in the serum concentration of CRP, AAT, Ceruloplasmin, C3 and Fibrinogen compared with control group (p<0.01), but the AGG increased only in HBs Ag - group .The serum concentration of Haptoglobin in both groups of patients was decreased in comparison with control group (p<0.01)and it was lesser in HBs Ag + patients. Transferrin as negative acute-phase protein was decreased significantly only in HBs Ag - patients (p<0.01). As it was observed in contrast with other inflammatory disease the plasma concentration of Haptoglobin in both groups of patients decreased in spite of inflammatory changes by liver tissue in ACUTE VIRAL HEPATITIS and AAG didn't show any increase. Although the serum concentration of CRP, AAT, C3, Ceruloplasmin and Fibrinogen increased but these increase were much lesser than found in typical form of inflammatory disease. In general,it seems that change in acute-phase proteins in ACUTE VIRAL HEPATITIS is not in typical form of inflammatory disease.

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APA: Copy

ABOU ALFATHI, A.A., & MOHSENEI MOVAHHED, A.. (2000). THE STUDY OF ACUTE PHASE PROTEINS IN PATIENTS SUFFERING FROM ACUTE VIRAL HEPATITIS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 34(46), 3-10. SID. https://sid.ir/paper/46986/en

Vancouver: Copy

ABOU ALFATHI A.A., MOHSENEI MOVAHHED A.. THE STUDY OF ACUTE PHASE PROTEINS IN PATIENTS SUFFERING FROM ACUTE VIRAL HEPATITIS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2000;34(46):3-10. Available from: https://sid.ir/paper/46986/en

IEEE: Copy

A.A. ABOU ALFATHI, and A. MOHSENEI MOVAHHED, “THE STUDY OF ACUTE PHASE PROTEINS IN PATIENTS SUFFERING FROM ACUTE VIRAL HEPATITIS,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 34, no. 46, pp. 3–10, 2000, [Online]. Available: https://sid.ir/paper/46986/en

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