COMPARISON OF CARDIAC ENZYMES PATTERN AND LEVELS OF TROPONIN I IN SERUM AFTER CORONARY ARTERY BYPASS GRAFTING BY ON-PUMP AND OFF - PUMP TECHNIQUES

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PARVIZI R.; RAHBANI NOUBAR M.; HASANZADEH SALMASI S.; KHATIBI F.

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Paper Information

Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2004 | Volume:- | Issue:61 Page(s): 17-21

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Title

COMPARISON OF CARDIAC ENZYMES PATTERN AND LEVELS OF TROPONIN I IN SERUM AFTER CORONARY ARTERY BYPASS GRAFTING BY ON-PUMP AND OFF - PUMP TECHNIQUES

Author(s)

PARVIZI R. | RAHBANI NOUBAR M. | HASANZADEH SALMASI S. | KHATIBI F. | Issue Writer Certificate

Keywords

ON-PUMP CABGQ2

OFF-PUMP CABGQ4

CKQ3

CK-MBQ3

LDHQ2

ASTQ2

TROPONIN IQ2

Abstract

Background and Objectives: Coronary artery bypass grafting (CABG) is usually performed through cardiopulmonary bypass (CPB). CPB, However, has been associated with several adverse effects. Recently, OFF-PUMP CABG technique is offered as an alternative to the standard ON-PUMP CABG technique. The purpose of this study was to evaluate the safety of the off-pump technique by estimating serum enzymes e.g. Creatin Kinase (CK), CK-MB, Lactate dehydrogenase (LDH), Aspartate Transaminase (AST), measurement of cardiac TROPONIN I and some postoperative complications.Materials and Methods: Ninety patients (75 males and 15 females) with angiographically defined CAD admitted to Shahid Madani Heart Hospital in Tabriz for coronary artery bypass grafting were selected. The off-pump technique was performed in 50 patients with mean age of 58‏. In 40 other patients with mean age of 56, the on-pump technique was applied. The blood samples were collected from the patients before, 6, 12 and 24 hours after the operation. The activities of CK, CK-MB, LDH, AST in all serum samples were measured by Cobas Mira autoanalyser, and cardiac TROPONIN I concentration also was measured by Evernest model 3200 motion. Data regarding patient age, sex, familial history of cardiovascular diseases, number of vessels grafted, procedural time, transfusion of blood and blood pressure were recorded for the both groups of patients. Postoperative data regarding the incidence of complications including myocardial infarction, need for inotrop adminstration and death were also recorded.Results: In this study the activities of serum enzymes such as CK, CK-MB, LDH and AST after ON-PUMP CABG technique were higher than those of off-pump technique (P< 0.05 in all cases). The levels of TROPONIN I were significantly higher after ON-PUMP CABG throughout the entire measurement period (P<0.01) compared with off-pump procedure. In both groups of patients no myocardial infarction was occurred during operation. In the off-pump technique procedural time was shorter and transfusion of blood was less than those of on-pump technique, but no difference was noticed among the other recorded data.Conclusion: Significant reduction in the release of enzymes and TROPONIN I during operation by off-pump technique suggests that the technique causes less myocardial injury. On the basis of little changes in the activities of cardiac enzymes and TROPONIN I in serum and presented data including a marked decrease in blood transfusion and shorter procedural time, it is concluded that OFF-PUMP CABG is a safe and effective technique in selected patients with appropriate coronary lesions.

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APA: Copy

PARVIZI, R., RAHBANI NOUBAR, M., HASANZADEH SALMASI, S., & KHATIBI, F.. (2004). COMPARISON OF CARDIAC ENZYMES PATTERN AND LEVELS OF TROPONIN I IN SERUM AFTER CORONARY ARTERY BYPASS GRAFTING BY ON-PUMP AND OFF - PUMP TECHNIQUES. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, -(61), 17-21. SID. https://sid.ir/paper/47031/en

Vancouver: Copy

PARVIZI R., RAHBANI NOUBAR M., HASANZADEH SALMASI S., KHATIBI F.. COMPARISON OF CARDIAC ENZYMES PATTERN AND LEVELS OF TROPONIN I IN SERUM AFTER CORONARY ARTERY BYPASS GRAFTING BY ON-PUMP AND OFF - PUMP TECHNIQUES. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2004;-(61):17-21. Available from: https://sid.ir/paper/47031/en

IEEE: Copy

R. PARVIZI, M. RAHBANI NOUBAR, S. HASANZADEH SALMASI, and F. KHATIBI, “COMPARISON OF CARDIAC ENZYMES PATTERN AND LEVELS OF TROPONIN I IN SERUM AFTER CORONARY ARTERY BYPASS GRAFTING BY ON-PUMP AND OFF - PUMP TECHNIQUES,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. -, no. 61, pp. 17–21, 2004, [Online]. Available: https://sid.ir/paper/47031/en

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