THE STUDY OF P53 POLYMORPHISM IN CODON 72 IN PATIENTS WITH THYROID CANCER IN A REPORT FROM EAST AZERBAIJAN PROVINCE IRAN

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HOSSEINPOUR FEIZI MOHAMMAD ALI; TOFIGH ROGHAYEH; POULADI NASSER; RAVANBAKHSH REYHANEH; AZARFAM PARVIN; MONTAZERI VAHIDEH

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Title

THE STUDY OF P53 POLYMORPHISM IN CODON 72 IN PATIENTS WITH THYROID CANCER IN A REPORT FROM EAST AZERBAIJAN PROVINCE IRAN

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Keywords

THYROID CANCERQ2

P53 GENEQ2

CODON 72Q2

POLYMORPHISMQ2

Abstract

seem that Ethnic and geographic factors are important elements. Cancer associated with mutation in tumor suppressor genes and oncogene. In addition to mutation, genetic POLYMORPHISMs are involved in incidence of cancer. The purpose of this investigation was studying POLYMORPHISM at CODON 72 of P53 GENE in patients with THYROID CANCER in East Azerbaijan province.Material and Methods: In a case-control study 60 patients with THYROID CANCER and 99 healthy individuals were studied as controls. After DNAs extraction from peripheral blood cells different genotypes of the 72th codon of P53 GENE were determined by amplification refractory mutation system (ARMS) and presence of probable mutation, single strand conformation POLYMORPHISM (SSCP) technique was also conducted to confirm the results; Exon 4 of P53 GENE was investigated by DNA sequencing.Results: In the control group, the genotype distribution of p53 POLYMORPHISM for Arg/Arg, Arg/Pro and Pro/Pro genotypes was 30.3%, 50.5% and 19.2% respectively. In the caner groups, the distribution was 31.67%, 51.67%, 16.67%, respectively for the same order of genotypes.Conclusion: This study indicates that POLYMORPHISM at CODON 72 P53 GENE is not a genetic predisposing factor for THYROID CANCER in this population.

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APA: Copy

HOSSEINPOUR FEIZI, MOHAMMAD ALI, TOFIGH, ROGHAYEH, POULADI, NASSER, RAVANBAKHSH, REYHANEH, AZARFAM, PARVIN, & MONTAZERI, VAHIDEH. (2013). THE STUDY OF P53 POLYMORPHISM IN CODON 72 IN PATIENTS WITH THYROID CANCER IN A REPORT FROM EAST AZERBAIJAN PROVINCE IRAN. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 35(2), 24-29. SID. https://sid.ir/paper/47394/en

Vancouver: Copy

HOSSEINPOUR FEIZI MOHAMMAD ALI, TOFIGH ROGHAYEH, POULADI NASSER, RAVANBAKHSH REYHANEH, AZARFAM PARVIN, MONTAZERI VAHIDEH. THE STUDY OF P53 POLYMORPHISM IN CODON 72 IN PATIENTS WITH THYROID CANCER IN A REPORT FROM EAST AZERBAIJAN PROVINCE IRAN. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;35(2):24-29. Available from: https://sid.ir/paper/47394/en

IEEE: Copy

MOHAMMAD ALI HOSSEINPOUR FEIZI, ROGHAYEH TOFIGH, NASSER POULADI, REYHANEH RAVANBAKHSH, PARVIN AZARFAM, and VAHIDEH MONTAZERI, “THE STUDY OF P53 POLYMORPHISM IN CODON 72 IN PATIENTS WITH THYROID CANCER IN A REPORT FROM EAST AZERBAIJAN PROVINCE IRAN,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 35, no. 2, pp. 24–29, 2013, [Online]. Available: https://sid.ir/paper/47394/en

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