ASSOCIATION OF 137 POLYMORPHISM IN THE INTERLEUKIN-18 GENE PROMOTER WITH DIABETES MELHITUS TYPE 1 IN EAST AZERBAIJAN POPULATION

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RAHBANI NABAR MOHAMMAD; REZAIE ALI; BAZZAZ SATTAR; AGHAMOHAMMAD ZADEH NASER

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2013 | Volume:35 | Issue:2 Page(s): 38-43

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Title

ASSOCIATION OF 137 POLYMORPHISM IN THE INTERLEUKIN-18 GENE PROMOTER WITH DIABETES MELHITUS TYPE 1 IN EAST AZERBAIJAN POPULATION

Author(s)

RAHBANI NABAR MOHAMMAD | REZAIE ALI | BAZZAZ SATTAR | AGHAMOHAMMAD ZADEH NASER | Issue Writer Certificate

Keywords

IL-18Q2

POLYMORPHISMQ2

TYPE 1 DIABETES MELLITUSQ2

Abstract

Background and Objectives: Interleukin-18 (IL-18) plays a key role in autoimmunity, inflammation and infection diseases and its higher levels are reported during the subclinical stage of TYPE 1 DIABETES MELLITUS. The aim of this study was to evaluate the recently described single-nucleotide-polymorphisms of promoter of IL-18 gene at position-137, in type 1 diabetic patients, which has been suggested to cause differences in transcription factor binding and IL-18 gene activity.Material and Methods: In this study, 104 type 1 diabetic patients (33female and 71 male) with mean age of 19.6±10.4 years, and 92 ages and sex matched, healthy individuals without family history of diabetes and autoimmune diseases were selected as controls. The single- nucleotide-polymorphism (SNP) at position-137 (G/C) in the promoter region of IL-18 gene was analyzed by sequence-specific PCR.Results: The genotype distribution differed significantly between patient and controls (p=0.038). The difference reflected as an increase in The GG genotypes at position-137 in promoter of IL-18 gene.Conclusion: The results of these studies suggest an association between type 1 diabetes and POLYMORPHISMs in the promoter region of IL-18.

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APA: Copy

RAHBANI NABAR, MOHAMMAD, REZAIE, ALI, BAZZAZ, SATTAR, & AGHAMOHAMMAD ZADEH, NASER. (2013). ASSOCIATION OF 137 POLYMORPHISM IN THE INTERLEUKIN-18 GENE PROMOTER WITH DIABETES MELHITUS TYPE 1 IN EAST AZERBAIJAN POPULATION. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 35(2), 38-43. SID. https://sid.ir/paper/47403/en

Vancouver: Copy

RAHBANI NABAR MOHAMMAD, REZAIE ALI, BAZZAZ SATTAR, AGHAMOHAMMAD ZADEH NASER. ASSOCIATION OF 137 POLYMORPHISM IN THE INTERLEUKIN-18 GENE PROMOTER WITH DIABETES MELHITUS TYPE 1 IN EAST AZERBAIJAN POPULATION. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;35(2):38-43. Available from: https://sid.ir/paper/47403/en

IEEE: Copy

MOHAMMAD RAHBANI NABAR, ALI REZAIE, SATTAR BAZZAZ, and NASER AGHAMOHAMMAD ZADEH, “ASSOCIATION OF 137 POLYMORPHISM IN THE INTERLEUKIN-18 GENE PROMOTER WITH DIABETES MELHITUS TYPE 1 IN EAST AZERBAIJAN POPULATION,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 35, no. 2, pp. 38–43, 2013, [Online]. Available: https://sid.ir/paper/47403/en

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