TOPICAL NICOTINAMIDE GEL COMPARED WITH CLINDAMYCIN GEL IN THE TREATMENT OF INFLAMMATORY ACNE

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KHODAEIANI E.; AMIRNYA M.; SAEIDI M.; RAZI A.; ADERANGI M.

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2002 | Volume:- | Issue:55 Page(s): 25-30

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Title

TOPICAL NICOTINAMIDE GEL COMPARED WITH CLINDAMYCIN GEL IN THE TREATMENT OF INFLAMMATORY ACNE

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Keywords

TREATMENTQ4

ACNEQ4

NICOTINAMIDEQ4

CLINDAMYCINQ4

Abstract

Background and Objectives: Systemic and topical antimicrobials are effective in the TREATMENT of inflammatory ACNE vulgaris. Widespread use of these agents is increasingly associated with the emergence of resistant pathogens. Thus, it highlights the need for an alternative nonantimicrobial agents for the TREATMENT of ACNE. NICOTINAMIDE gel provides potent anti-inflammatory activity without the risk of inducing bacterial resistance.Materials and Methods: In this double blind investigation, the safety and efficacy of topically applied 4% NICOTINAMIDE gel was compared to 1% CLINDAMYCIN gel for the TREATMENT of 80 patients with moderate to severe inflammatory ACNE vulgaris. Out of these 80 patients, 30 were males and 50 females. Most of the patients were in 16-20 years age group. Forty patients were treated by 4% NICOTINAMIDE gel and other 40 were given 1% CLINDAMYCIN gel. Patients were unaware of the name of medicine except the code A and B. Thus, a total of 80 patients were randomly assigned to apply either 1% CLINDAMYCIN gel (N=40, Group A) or 4% NICOTINAMIDE gel (N=40, Group B) twice daily for 8 weeks. Efficacy was evaluated after 4 and 8 weeks using a physicians global evaluation, ACNE lesion count and an ACNE severity rating. Results: At the start of TREATMENT, for patients under CLINDAMYCIN or NICOTINAMIDE gel therapy, ACNE severity count median was 5.75 1.45 and 6.1 1.19 respectively. After 4 weeks therapy, ACNE severity count average for group A reached to 3.4 and for group B to 4.05. After 8 weeks TREATMENT, ACNE severity count average in the first group reached to 2.05 1.72 and in second group it was 2.05 1.39 and p=1. After 8 weeks, both TREATMENTs produced comparable beneficial results in the physicians global evaluation of inflammatory ACNE.Conclusion: These results demonstrate that 4% NICOTINAMIDE gel is more efficient as compared to 1% CLINDAMYCIN in the TREATMENT of ACNE vulgaris. Because topical CLINDAMYCIN like other antimicrobials is associated with emergence of resistant microorganisms, NICOTINAMIDE gel is a desirable alternative TREATMENT for ACNE vulgaris.

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APA: Copy

KHODAEIANI, E., AMIRNYA, M., SAEIDI, M., RAZI, A., & ADERANGI, M.. (2002). TOPICAL NICOTINAMIDE GEL COMPARED WITH CLINDAMYCIN GEL IN THE TREATMENT OF INFLAMMATORY ACNE . MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, -(55), 25-30. SID. https://sid.ir/paper/47571/en

Vancouver: Copy

KHODAEIANI E., AMIRNYA M., SAEIDI M., RAZI A., ADERANGI M.. TOPICAL NICOTINAMIDE GEL COMPARED WITH CLINDAMYCIN GEL IN THE TREATMENT OF INFLAMMATORY ACNE . MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;-(55):25-30. Available from: https://sid.ir/paper/47571/en

IEEE: Copy

E. KHODAEIANI, M. AMIRNYA, M. SAEIDI, A. RAZI, and M. ADERANGI, “TOPICAL NICOTINAMIDE GEL COMPARED WITH CLINDAMYCIN GEL IN THE TREATMENT OF INFLAMMATORY ACNE ,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. -, no. 55, pp. 25–30, 2002, [Online]. Available: https://sid.ir/paper/47571/en

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