A CASE OF NONHEMOPHILIC IDIOPATHIC FACTOR VIII ANTIBODY

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EYVAZI ZIAEI J.; SANAAT Z.

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2002 | Volume:- | Issue:53 Page(s): 65-68

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Title

A CASE OF NONHEMOPHILIC IDIOPATHIC FACTOR VIII ANTIBODY

Author(s)

EYVAZI ZIAEI J. | SANAAT Z. | Issue Writer Certificate

Keywords

ANTIBODY FACTOR VIIIQ4

ECCHYMOSISQ3

INTRAMUSCULAR HEMATOMAQ4

Abstract

Presence of inhibitor to factor VIII (FVIII) is a rare occurrence. The incidence of acquired inhibitors in the population is 0.2-1 per million / year and majority of such patients are older than 60 years. Presence of these antibodies is observed sometimes in association with an autoimmune disorder, hematologic and nonhematologic malignancies, pregnancy, drug usage, infection and or idiopathy. Patients commonly present with hemorrhage into soft tissue ECCHYMOSIS, overt bleeding after trauma or surgery. Laboratory tests shows prolonged partial thromboplastin time (PTT), decreased level of factor VIII and increased level of factor VIII inhibitors. These patients are treated with prednisolone and cyclophosphamide. Hereby, we report a 75 years old man with ECCHYMOSIS and swelling of left knee, prolonged PTT, decreased FVIII level and increased FVIII inhibitor. He was treated with prednisolone and was followed up for any compliant or symptoms.He improved symptomatically within 15 days. After one month, he had no symptoms of disorder and normal PTT. However, after discontinuation of prednisolone, PTT level raised again and cyclophosphamide was prescribed. PTT was normal after one month.

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APA: Copy

EYVAZI ZIAEI, J., & SANAAT, Z.. (2002). A CASE OF NONHEMOPHILIC IDIOPATHIC FACTOR VIII ANTIBODY. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, -(53), 65-68. SID. https://sid.ir/paper/47610/en

Vancouver: Copy

EYVAZI ZIAEI J., SANAAT Z.. A CASE OF NONHEMOPHILIC IDIOPATHIC FACTOR VIII ANTIBODY. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;-(53):65-68. Available from: https://sid.ir/paper/47610/en

IEEE: Copy

J. EYVAZI ZIAEI, and Z. SANAAT, “A CASE OF NONHEMOPHILIC IDIOPATHIC FACTOR VIII ANTIBODY,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. -, no. 53, pp. 65–68, 2002, [Online]. Available: https://sid.ir/paper/47610/en

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