EFFECT OF LONG TERM ADDICTION WITH MORPHINE ON FETAL RAT DEVELOPMENT

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PEYROVI T.; SOLAEYMANIRAD J.

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2002 | Volume:35 | Issue:52 Page(s): 21-25

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Title

EFFECT OF LONG TERM ADDICTION WITH MORPHINE ON FETAL RAT DEVELOPMENT

Author(s)

PEYROVI T. | SOLAEYMANIRAD J. | Issue Writer Certificate

Keywords

MORPHINEQ4

ADDICTIONQ2

RATQ4

FETUSQ4

Abstract

Background and Objectives: In the past, MORPHINE was used as the only pain relieving agent for pains with different origins. Although the importance of MORPHINE as an inclusive pain relieving substance has been reduced, it is still considered as a strong and a widely used opioid. Therefore, the aim of the present study was to investigate the effect of MORPHINE ADDICTION on embryonic development.Materials and Methods: In the present study Wistar RATs, taken as experimental model, were divided into three groups. Each group was treated by MORPHINE as follows: Group 1 and 2, to which 0.1 mg MORPHINE was added to drinking water and to the 3rd group, it was injected subcutaneously. For having a constant effect of ADDICTION, the dose was increased continously. In the 1st group only male RATs, in the 2nd group both male and female RATs and in the 3rd group only female RATs received MORPHINE. In the newborns from all the three groups, birth weight crown - rump length, crown - heel length and the length of limbs were measured.Results: The results of this study showed that male ADDICTION (Group 1) had no effect on embryonic weight and length. However, female ADDICTION and ADDICTION of both male and female (Group 2) resulted in a significant (p<0.05) reduction of weight and length. Furthermore, female ADDICTION caused an increased mortality RATe, especially after weaning.Conclusion: Reduction in birth weight and length in newborns, is an indication of intrauterine growth retardation imposed by mothers long-term ADDICTION.

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APA: Copy

PEYROVI, T., & SOLAEYMANIRAD, J.. (2002). EFFECT OF LONG TERM ADDICTION WITH MORPHINE ON FETAL RAT DEVELOPMENT . MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 35(52), 21-25. SID. https://sid.ir/paper/47657/en

Vancouver: Copy

PEYROVI T., SOLAEYMANIRAD J.. EFFECT OF LONG TERM ADDICTION WITH MORPHINE ON FETAL RAT DEVELOPMENT . MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;35(52):21-25. Available from: https://sid.ir/paper/47657/en

IEEE: Copy

T. PEYROVI, and J. SOLAEYMANIRAD, “EFFECT OF LONG TERM ADDICTION WITH MORPHINE ON FETAL RAT DEVELOPMENT ,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 35, no. 52, pp. 21–25, 2002, [Online]. Available: https://sid.ir/paper/47657/en

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