CHRONIC LYMPHOCYTIC LEUKEMIA AND TREATMENT EFFECT OF FLUDARABIN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ASVADI KERMANI I.; DEHDILANI M.; DOULATKHAH ROUYA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2009 | Volume:31 | Issue:1 Page(s): 17-23

Download Full-Text

Persian Verion

View:

2,085

Download:

Cites:

Information Journal Paper

Title

CHRONIC LYMPHOCYTIC LEUKEMIA AND TREATMENT EFFECT OF FLUDARABIN

Author(s)

ASVADI KERMANI I. | DEHDILANI M. | DOULATKHAH ROUYA | Issue Writer Certificate

Keywords

CHRONIC LYMPHOCYTIC LEUKEMIAQ3

FLUDARABINQ2

REMISSIONQ3

Abstract

Background and Objectives: CLL (CHRONIC LYMPHOCYTIC LEUKEMIA) is the most common form of leukemia in the western world and because of prolonged survival of patients, the prevalence is high. Chemotherapy is usually not indicated in early and stable disease and using chlorambucil with or without steroids has been the drug of choice in the treatment of CLL for many years .Clinical studies have shown that using FLUDARABIN can cause a complete response in significant number of untreated and/or previously treated CLL patients. The aim of this study was evaluation of CLL patients and determining the effects of treatment with FLUDARABIN. Materials and Methods: A retrospective (descriptive/cross sectional) study of CLL patients who were admitted to Hematology and Oncology Research Center of Tabriz University of Medical Sciences, between 1995-2005 was made and 126 patients enrolled. Collection of data was carried out according to special questionnaire and response to FLUDARABIN was analyzed by SPSS-11 software.Results: The mean age of patients at diagnosis was 63.7±8.9 years, 69.8% were males.Illness and fatigue were the most common presenting symptoms in 54% and lymphadenopathy was the most common clinical sign in 88.9%. Most of the patients were in stage C in Binet system (52.4%) and/or stage IV in Rai system (44.4%). Chemotherapy with chlorambucil and prednisolone was the most common regimen used (60.3%) and 49.2% of patients were in partial REMISSION with this treatment. Forty two patients treated with FLUDARABIN and 50% were in partial REMISSION, 35% in static disease, 10% in progressive disease and 5% in complete REMISSION (P=0.053).Conclusion: The median survival with FLUDARABIN was 43.9±27.2, months and in the case of chlorambucil + prednisolone and cyclophosphamide + vincristine + prednisone (CVP) or cyclophosphamide + vincristine + prednisone + doxorubicine (CHOP), it was 45±26.5, months and 50±32.2, months respectively (P>0.05). P value in relation with survival and response to FLUDARABIN was 0.05. Above all, FLUDARABIN is the treatment of choice as first and second line therapy and for patients who have failed therapy with standard regimens.

Cites

No record.

References

No record.

Cite

APA: Copy

ASVADI KERMANI, I., DEHDILANI, M., & DOULATKHAH, ROUYA. (2009). CHRONIC LYMPHOCYTIC LEUKEMIA AND TREATMENT EFFECT OF FLUDARABIN. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 31(1), 17-23. SID. https://sid.ir/paper/47669/en

Vancouver: Copy

ASVADI KERMANI I., DEHDILANI M., DOULATKHAH ROUYA. CHRONIC LYMPHOCYTIC LEUKEMIA AND TREATMENT EFFECT OF FLUDARABIN. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;31(1):17-23. Available from: https://sid.ir/paper/47669/en

IEEE: Copy

I. ASVADI KERMANI, M. DEHDILANI, and ROUYA DOULATKHAH, “CHRONIC LYMPHOCYTIC LEUKEMIA AND TREATMENT EFFECT OF FLUDARABIN,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 31, no. 1, pp. 17–23, 2009, [Online]. Available: https://sid.ir/paper/47669/en

Related Journal Papers