FORMULATION OF DICLOFENAC DIETHYLAMINE EMULGEL EVALUATION OF VARIOUS PENERATION ENHANCERS ON PERCUPANEOUS ABSORPTION OF THE DRUG FROM EMULGELS

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AZARMI SH.; SHOKRI J.; Hallaj Nezhadi s.; MOHAMMADI GH.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:1 Page(s): 85-95

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Information Journal Paper

Title

FORMULATION OF DICLOFENAC DIETHYLAMINE EMULGEL EVALUATION OF VARIOUS PENERATION ENHANCERS ON PERCUPANEOUS ABSORPTION OF THE DRUG FROM EMULGELS

Author(s)

AZARMI SH. | SHOKRI J. | Hallaj Nezhadi s. | MOHAMMADI GH. | Issue Writer Certificate

Keywords

DICLOFENACQ2

EMULGELQ2

SKIN PENETRATIONQ2

PENETRATION ENHANCERQ2

CINEOLQ2

TRANSCUTOLQ2

MYRJQ2

Abstract

The purpose of the present study was to prepare DICLOFENAC diethyl amine EMULGEL with better SKIN PENETRATION compared to the marketed product in Iran. To achieve such a product, several formulations containing different kinds and amounts of gelling agents, have been prepared. By changing the type and amount of gelling agent, type and ratio of organic phase composition, and solvent amount the best formulation with better stability has been selected. The SKIN PENETRATION study was carried out using SKIN PENETRATION study apparatus equipped with Franz cells. The concentration of drug in the receptor phase of Franz cells was determined using UV spectrophotometer and HPLC. To evaluate the effect of type and concentration of SKIN PENETRATION enhancer agents on the penetration of drug through rat skin, TRANSCUTOL, MYRJ 52 and CINEOL was used with different concentrations. After calculating flux and EF values and comparing the graph of cumulative amount of drug penetrated through the skin, the formulation which had 0.25% MYRJ 52 as SKIN PENETRATION enhancer was selected as the best formulation with higher SKIN PENETRATION.

Cites

COMPARISON OF NEW FORMULATION OF DICLOFENAC DIETHYLAMONIUM EMULGEL WITH STANDARD PREPARATION

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APA: Copy

AZARMI, SH., SHOKRI, J., Hallaj Nezhadi, s., & MOHAMMADI, GH.. (2005). FORMULATION OF DICLOFENAC DIETHYLAMINE EMULGEL EVALUATION OF VARIOUS PENERATION ENHANCERS ON PERCUPANEOUS ABSORPTION OF THE DRUG FROM EMULGELS. PHARMACEUTICAL SCIENCES, -(1), 85-95. SID. https://sid.ir/paper/48425/en

Vancouver: Copy

AZARMI SH., SHOKRI J., Hallaj Nezhadi s., MOHAMMADI GH.. FORMULATION OF DICLOFENAC DIETHYLAMINE EMULGEL EVALUATION OF VARIOUS PENERATION ENHANCERS ON PERCUPANEOUS ABSORPTION OF THE DRUG FROM EMULGELS. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(1):85-95. Available from: https://sid.ir/paper/48425/en

IEEE: Copy

SH. AZARMI, J. SHOKRI, s. Hallaj Nezhadi, and GH. MOHAMMADI, “FORMULATION OF DICLOFENAC DIETHYLAMINE EMULGEL EVALUATION OF VARIOUS PENERATION ENHANCERS ON PERCUPANEOUS ABSORPTION OF THE DRUG FROM EMULGELS,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 85–95, 2005, [Online]. Available: https://sid.ir/paper/48425/en

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