THE EFFECT OF AL3+ ON THE PROPRANOLOL HYDROCHLORIDE RELEASE FROM POLYANIONIC POLYMER MATRICES

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BARZEGAR JALALI M.; SIAHI SHADBAD M.R.; AZARMI SH.; BARZEGAR JALALI A.; MOHAMADI GH.; DANESH BAHREYNI M.A.; ADIBKIA KH.; RASEKHIAN M.; RAEISI R.; ZARE M.

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Journal: PHARMACEUTICAL SCIENCES Year:2007 | Volume:- | Issue:3 Page(s): 7-17

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Title

THE EFFECT OF AL3+ ON THE PROPRANOLOL HYDROCHLORIDE RELEASE FROM POLYANIONIC POLYMER MATRICES

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Keywords

PROPRANOLOL HYDROCHLORIDEQ2

ANIONIC POLYMERSQ2

ALUMINUM CATIONQ2

CROSSLINKINGQ2

MATRIXQ2

RELEASEQ2

Abstract

Objectives: Sustaining PROPRANOLOL HYDROCHLORIDE (PLH) decreases its frequency of daily dosage, side effects and enhances patient compliance. In order to control the RELEASE of PLH the effect of Al3+ and type of anionic polymer on the drug RELEASE was studied.Methods: Matrices of sodium carboxymethyl cellulose (NaCMC), sodium alginate (NaAlg) and tragacant (Trag) containing drug as well as different amounts of Al3+ were prepared and the drug RELEASE was measured in distilled water using USP I dissolution tester. Concentration of dissolved drug was assayed spectrophotometrically. The RELEASE of different matrices was compared with the aid of some model independent parameters e.g. F360' (drug fraction RELEASEd in 360') and model dependent parameters.Results: Various amounts of Al3+ had different effects. In the range of 0-0.125 milli equivalent (meq) Al3+ in NaCMC matrices the F360' was reduced from 0.63 to 0.21 via in situ CROSSLINKING between Al3+ and polymer and in the higher ranges e.g. 0.5 meq the RELEASE increased to 0.79 probably through disintegrating effect of Al3+. A similar effect was seen for NaAlg matrices. Al3+ had very little influence on the RELEASE of Trag matrices. Analysis by kinetic models indicated complex mechanisms such as water penetration, diffusion, erosion, dissolution, cross linking and disintegration. Conclusion: With the choice of the most suitable anionic polymer (NaCMC) together with given amount of Al3+ the RELEASE of PLH from matrices can be controlled at any desired rate. Matrices of NaAlg were the next suitable formulations. However, Trag was not a suitable polymer because it did not produce appreciable cross linkage with Al3+.

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APA: Copy

BARZEGAR JALALI, M., SIAHI SHADBAD, M.R., AZARMI, SH., BARZEGAR JALALI, A., MOHAMADI, GH., DANESH BAHREYNI, M.A., ADIBKIA, KH., RASEKHIAN, M., RAEISI, R., & ZARE, M.. (2007). THE EFFECT OF AL³⁺ ON THE PROPRANOLOL HYDROCHLORIDE RELEASE FROM POLYANIONIC POLYMER MATRICES. PHARMACEUTICAL SCIENCES, -(3), 7-17. SID. https://sid.ir/paper/48437/en

Vancouver: Copy

BARZEGAR JALALI M., SIAHI SHADBAD M.R., AZARMI SH., BARZEGAR JALALI A., MOHAMADI GH., DANESH BAHREYNI M.A., ADIBKIA KH., RASEKHIAN M., RAEISI R., ZARE M.. THE EFFECT OF AL³⁺ ON THE PROPRANOLOL HYDROCHLORIDE RELEASE FROM POLYANIONIC POLYMER MATRICES. PHARMACEUTICAL SCIENCES[Internet]. 2007;-(3):7-17. Available from: https://sid.ir/paper/48437/en

IEEE: Copy

M. BARZEGAR JALALI, M.R. SIAHI SHADBAD, SH. AZARMI, A. BARZEGAR JALALI, GH. MOHAMADI, M.A. DANESH BAHREYNI, KH. ADIBKIA, M. RASEKHIAN, R. RAEISI, and M. ZARE, “THE EFFECT OF AL³⁺ ON THE PROPRANOLOL HYDROCHLORIDE RELEASE FROM POLYANIONIC POLYMER MATRICES,” PHARMACEUTICAL SCIENCES, vol. -, no. 3, pp. 7–17, 2007, [Online]. Available: https://sid.ir/paper/48437/en

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