EFFECT OF POLYMER VISCOSITY, POLYMER PARTICLE SIZE AND COMPACTION FORCE ON DICLOFENAC SODIUM RELEASE FROM ETHYLCELLULOSE MATRICES

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SADEGHI FATEMEH; AFRASIABI GAREKANI H.; FARZADNIA Z.

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Journal: PHARMACEUTICAL SCIENCES Year:2001 | Volume:- | Issue:1 Page(s): 45-56

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Information Journal Paper

Title

EFFECT OF POLYMER VISCOSITY, POLYMER PARTICLE SIZE AND COMPACTION FORCE ON DICLOFENAC SODIUM RELEASE FROM ETHYLCELLULOSE MATRICES

Author(s)

SADEGHI FATEMEH | AFRASIABI GAREKANI H. | FARZADNIA Z. | Issue Writer Certificate

Keywords

MATRIXQ2

SUSTAIN RELEASEQ2

ETHYL CELLULOSEQ3

VISCOSITYQ3

COMPRESSION FORCEQ3

PARTICLE SIZEQ2

Abstract

Ethyl cellulose (EC) is a widely used polymer in the production of sustained release dosage form. This polymer has been used mostly in process of micro encapsulation and also in film coating of pellets and granules in order to control drug release rate. Recently the application of EC in the production of hydrophobic and inert matrices has been investigated and the factors affecting drug release from these matrices have been evaluated. The purpose of this study was to investigate the effect of polymer VISCOSITY, polymer PARTICLE SIZE and compaction force on the release of sparingly soluble drug (Diclofenac sodium) from ETHYL CELLULOSE matrices. The results showed that matrices prepared from higher VISCOSITY grade of EC released their drug content in faster rate than matrices prepared from lower VISCOSITY grade. All matrices disintegrated during dissolution test but the time taken for complete disintegration was dependent on VISCOSITY of the polymer, being longer for lower VISCOSITY grades of polymer. This was attributed to the decrease in tablet crushing strength with increasing VISCOSITY of the polymer which facilitated the diffusion of dissolution medium into the matrices. Investigation of the effect of polymer PARTICLE SIZE on drug release showed that matrices prepared from coarser particles released their drug content slower than those prepared from smaller particles. This effect was due to more rapid disintegration of matrices prepared from smaller PARTICLE SIZE of polymer. The results of this study also showed that compaction force has greatly affected drug release rate from EC matrices. Increasing the compaction force increased the crushing strength of matrices and subsequently the rate of drug release decreased. In all matriecs the main mechanism controlling drug release rate was found to be erosin.

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APA: Copy

SADEGHI, FATEMEH, AFRASIABI GAREKANI, H., & FARZADNIA, Z.. (2001). EFFECT OF POLYMER VISCOSITY, POLYMER PARTICLE SIZE AND COMPACTION FORCE ON DICLOFENAC SODIUM RELEASE FROM ETHYLCELLULOSE MATRICES. PHARMACEUTICAL SCIENCES, -(1), 45-56. SID. https://sid.ir/paper/48468/en

Vancouver: Copy

SADEGHI FATEMEH, AFRASIABI GAREKANI H., FARZADNIA Z.. EFFECT OF POLYMER VISCOSITY, POLYMER PARTICLE SIZE AND COMPACTION FORCE ON DICLOFENAC SODIUM RELEASE FROM ETHYLCELLULOSE MATRICES. PHARMACEUTICAL SCIENCES[Internet]. 2001;-(1):45-56. Available from: https://sid.ir/paper/48468/en

IEEE: Copy

FATEMEH SADEGHI, H. AFRASIABI GAREKANI, and Z. FARZADNIA, “EFFECT OF POLYMER VISCOSITY, POLYMER PARTICLE SIZE AND COMPACTION FORCE ON DICLOFENAC SODIUM RELEASE FROM ETHYLCELLULOSE MATRICES,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 45–56, 2001, [Online]. Available: https://sid.ir/paper/48468/en

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