EVALUATION OF FORMULATION ADDITIVES' EFFECT ON STABILITY AND INHIBITION OF CRYSTAL GROWTH IN CHLORAMPHENICOL PALMITATE SUSPENSION

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SAEIDI M.; DALLAL-POOR MOHAMMADI N.; FARID J.

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Journal: PHARMACEUTICAL SCIENCES Year:2001 | Volume:- | Issue:1 Page(s): 23-32

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Information Journal Paper

Title

EVALUATION OF FORMULATION ADDITIVES' EFFECT ON STABILITY AND INHIBITION OF CRYSTAL GROWTH IN CHLORAMPHENICOL PALMITATE SUSPENSION

Author(s)

SAEIDI M. | DALLAL-POOR MOHAMMADI N. | FARID J. | Issue Writer Certificate

Keywords

SUSPENSIONQ3

CRYSTAL GROWTH STABILITYQ3

CHLORAMPHENICOL PALMITATEQ2

PVPQ3

BSAQ3

Abstract

SUSPENSIONs are an important class of pharmaceutical dosage forms. These disperse systems present much formulation, stability, manufacturing and packaging challenges. For evaluation of excipient's effect on SUSPENSION stability, different formulations were prepared. These preparations composed of 5.22 g/100cc CHLORAMPHENICOL PALMITATE (as drug model) and different amounts of NaCMC, propylene glycol, Tween 80, polyvinyl pyrrolidolle (PVP), Bovine serum albumin (BSA) and preserved water (Qs). The results showed a critical amount of suspending agent (0.4%), surfactant (0.4-0.5%) and vehicle (20-22.5%) for preparing a stable SUSPENSION. PVP and BSA showed an inhibition effect on crystal growth after freeze-thaw cycling technique.

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APA: Copy

SAEIDI, M., DALLAL-POOR MOHAMMADI, N., & FARID, J.. (2001). EVALUATION OF FORMULATION ADDITIVES' EFFECT ON STABILITY AND INHIBITION OF CRYSTAL GROWTH IN CHLORAMPHENICOL PALMITATE SUSPENSION. PHARMACEUTICAL SCIENCES, -(1), 23-32. SID. https://sid.ir/paper/48471/en

Vancouver: Copy

SAEIDI M., DALLAL-POOR MOHAMMADI N., FARID J.. EVALUATION OF FORMULATION ADDITIVES' EFFECT ON STABILITY AND INHIBITION OF CRYSTAL GROWTH IN CHLORAMPHENICOL PALMITATE SUSPENSION. PHARMACEUTICAL SCIENCES[Internet]. 2001;-(1):23-32. Available from: https://sid.ir/paper/48471/en

IEEE: Copy

M. SAEIDI, N. DALLAL-POOR MOHAMMADI, and J. FARID, “EVALUATION OF FORMULATION ADDITIVES' EFFECT ON STABILITY AND INHIBITION OF CRYSTAL GROWTH IN CHLORAMPHENICOL PALMITATE SUSPENSION,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 23–32, 2001, [Online]. Available: https://sid.ir/paper/48471/en

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