THE EFFECT OF CHRONIC AND ACUTE ADMINISTRATION OF FLUOXETINE ON ACUTE PAIN AND POSSIBLE ROLE OF OPOIOIDERGIC SYSTEM USING HOT PLATE TEST

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MOHAJEL NAEBI ALI REZA; BABAEI HOSSEIN; SAMIEI K.

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Journal: PHARMACEUTICAL SCIENCES Year:2001 | Volume:- | Issue:1 Page(s): 85-94

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Title

THE EFFECT OF CHRONIC AND ACUTE ADMINISTRATION OF FLUOXETINE ON ACUTE PAIN AND POSSIBLE ROLE OF OPOIOIDERGIC SYSTEM USING HOT PLATE TEST

Author(s)

MOHAJEL NAEBI ALI REZA | BABAEI HOSSEIN | SAMIEI K. | Issue Writer Certificate

Keywords

FLUOXETINEQ2

MORPHINEQ2

NALOXONEQ3

HOT PLATE TESTQ2

Abstract

There is much evidence indicating that the serotonergic system involves in the central regulation of nociceptive sensitivity. Several drugs are able to produce analgesic effect through serotonin re uptake inhibition or effect on it's receptors. Studies show that antidepressants such as desipramine, amitriptyline, clomipramine, citalopram and zimelidine have analgesic effect in experimental pain models; however, there isn't any report concerning analgesic effect of chronic and acute administered FLUOXETINE. The aim of this study was to investigate the effect of chronic and acute injected FLUOXETINE on HOT PLATE TEST. Results of this study showed that chronic (0.16, 0.2 and 0.24 mg/kg, i.p. for 5 days) and acute (0.2 and 0.24 mg/kg, i.p.) administration of FLUOXETINE, as a serotonin re uptake inhibitor, produced significant analgesia. FLUOXETINE (0.24 mg/kg, i.p.) increased analgesic effect of MORPHINE (1 mg/kg, i.p.) significantly. Furthermore, analgesic effect of FLUOXETINE (0.24 mg/kg, i.p. and 0.24 mg/kg, i.p., for 5 days) was reversed by NALOXONE (2 mg/kg, i.p.). Results obtained from this study showe that chronic and acute injection of FLUOXETINE induce analgesic effect on HOT PLATE TEST through activation of opioidergic neurons. The exact mechanism of interaction between serotonergic and opioidergic system is not clear and remains to be elucidated.

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APA: Copy

MOHAJEL NAEBI, ALI REZA, BABAEI, HOSSEIN, & SAMIEI, K.. (2001). THE EFFECT OF CHRONIC AND ACUTE ADMINISTRATION OF FLUOXETINE ON ACUTE PAIN AND POSSIBLE ROLE OF OPOIOIDERGIC SYSTEM USING HOT PLATE TEST. PHARMACEUTICAL SCIENCES, -(1), 85-94. SID. https://sid.ir/paper/48472/en

Vancouver: Copy

MOHAJEL NAEBI ALI REZA, BABAEI HOSSEIN, SAMIEI K.. THE EFFECT OF CHRONIC AND ACUTE ADMINISTRATION OF FLUOXETINE ON ACUTE PAIN AND POSSIBLE ROLE OF OPOIOIDERGIC SYSTEM USING HOT PLATE TEST. PHARMACEUTICAL SCIENCES[Internet]. 2001;-(1):85-94. Available from: https://sid.ir/paper/48472/en

IEEE: Copy

ALI REZA MOHAJEL NAEBI, HOSSEIN BABAEI, and K. SAMIEI, “THE EFFECT OF CHRONIC AND ACUTE ADMINISTRATION OF FLUOXETINE ON ACUTE PAIN AND POSSIBLE ROLE OF OPOIOIDERGIC SYSTEM USING HOT PLATE TEST,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 85–94, 2001, [Online]. Available: https://sid.ir/paper/48472/en

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