A STUDY ON THE EFFECT OF VITAMIN E ON THE REDUCTION OF RENAL LIPOFUSCIN IN DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JALALI M.; NIKRAVESH M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: PHARMACEUTICAL SCIENCES Year:2001 | Volume:- | Issue:4 Page(s): 21-30

Download Full-Text

Persian Verion

View:

5,138

Download:

Cites:

Information Journal Paper

Title

A STUDY ON THE EFFECT OF VITAMIN E ON THE REDUCTION OF RENAL LIPOFUSCIN IN DIABETIC RATS

Author(s)

JALALI M. | NIKRAVESH M. | Issue Writer Certificate

Keywords

DIABETESQ2

VITAMIN EQ2

LIPOFUSCINQ3

RATQ2

Abstract

Since DIABETES is a progressive disease, therefore early diagnosis is impotent in prevention of the metabolic changes associated with DIABETES is a high expression of LIPOFUSCIN in erythrocytes and specially renal proximal tubular cells. This change leads to the renal toxicity, nephropathy, and provides functional disorders in kidneys. Some studies suggest that the glycogenolysis and the increase in the plasma level of free O2 radicals in the absence of VITAMIN E cause the changes. on the other hand, VITAMIN E deficiency in renal proximal tubules decreases the cell survival. Since VITAMIN E is a physiological antioxidant and a membrane stabilizer, in this study we treated diabetic RATs with VITAMIN E. For this reason, 30 male whistar RATs were divided in to the groups, one control group and two experimental groups (alloxan-induced diabetic RATs), (n=10). Experimental group 1 were treated for 8 weeks, With 10 mg/kg of VITAMIN E daily. After 8 weeks all the RATs were anesthetized, dissected and their kidneys were fixed by formalin 10%. After fixation, all of specimens processed serially, sectioned and stained with Schmorel, s method.The results indicated a significant decrease in LIPOFUSCIN level of the experimental group 1 in comparison the group 2. This result indicates that VITAMIN E may prevent LIPOFUSCIN production and provide a renal protection against DIABETES.

Cites

No record.

References

No record.

Cite

APA: Copy

JALALI, M., & NIKRAVESH, M.. (2001). A STUDY ON THE EFFECT OF VITAMIN E ON THE REDUCTION OF RENAL LIPOFUSCIN IN DIABETIC RATS. PHARMACEUTICAL SCIENCES, -(4), 21-30. SID. https://sid.ir/paper/48488/en

Vancouver: Copy

JALALI M., NIKRAVESH M.. A STUDY ON THE EFFECT OF VITAMIN E ON THE REDUCTION OF RENAL LIPOFUSCIN IN DIABETIC RATS. PHARMACEUTICAL SCIENCES[Internet]. 2001;-(4):21-30. Available from: https://sid.ir/paper/48488/en

IEEE: Copy

M. JALALI, and M. NIKRAVESH, “A STUDY ON THE EFFECT OF VITAMIN E ON THE REDUCTION OF RENAL LIPOFUSCIN IN DIABETIC RATS,” PHARMACEUTICAL SCIENCES, vol. -, no. 4, pp. 21–30, 2001, [Online]. Available: https://sid.ir/paper/48488/en

Related Journal Papers