PERFORMANCE OF POLYMERS IN MICROCAPSULES OF ACETYL SALICYLIC ACID

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NOKHOUDCHI A.; ZAKERI MILANI P.; VALIZADEH H.; HASSANZADEH D.

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Journal: PHARMACEUTICAL SCIENCES Year:2001 | Volume:- | Issue:4 Page(s): 87-93

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Title

PERFORMANCE OF POLYMERS IN MICROCAPSULES OF ACETYL SALICYLIC ACID

Author(s)

NOKHOUDCHI A. | ZAKERI MILANI P. | VALIZADEH H. | HASSANZADEH D. | Issue Writer Certificate

Keywords

MICRO ENCAPSULATIONQ3

RELEASE RATEQ3

KINETIC OF RELEASEQ3

TABLETED MICROCAPSULESQ3

NO SOLVENT ADDITION TECHNIQUEQ3

CELLULOSE ACETATE PHTHALATEQ3

ETHYLCELLULOSEQ3

Abstract

Acetyl salicylic acid (ASA) was encapsulated with CELLULOSE ACETATE PHTHALATE (CAP), ETHYLCELLULOSE (EC) or their mixtures by an emulsion non-solvent addition method. The release profiles of prepared microcapsules with different ratios of drug to polymer (10:1 and 4:1) and tabulated microcapsules were evaluated at pH 1.2 or 6. The results showed that a reduction in the ratio of drug to polymer resulted in a reduction in RELEASE RATE. The microcapsules prepared with EC showed the lowest RELEASE RATE. The in vitro release studies showed that the drug RELEASE RATE decreased after tableting, because of the formation of a non-disintegrating matrix. Release of ASA at pH 6 is significantly higher in all microcapsules, even when using EC which is not water soluble. This is probably due to better solubility of ASA at pH 6 indicating incomplete film formation around the ASA particles. Release data were examined kinetically and the ideal kinetic models were estimated for drug release. The results showed that for TABLETED MICROCAPSULES the highest correlation coefficient was achieved with the zero-order release. For TABLETED MICROCAPSULES containing CAP or the mixture of CAP and EC contribution of erosion was higher than that of untalented microcapsules.

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APA: Copy

NOKHOUDCHI, A., ZAKERI MILANI, P., VALIZADEH, H., & HASSANZADEH, D.. (2001). PERFORMANCE OF POLYMERS IN MICROCAPSULES OF ACETYL SALICYLIC ACID. PHARMACEUTICAL SCIENCES, -(4), 87-93. SID. https://sid.ir/paper/48494/en

Vancouver: Copy

NOKHOUDCHI A., ZAKERI MILANI P., VALIZADEH H., HASSANZADEH D.. PERFORMANCE OF POLYMERS IN MICROCAPSULES OF ACETYL SALICYLIC ACID. PHARMACEUTICAL SCIENCES[Internet]. 2001;-(4):87-93. Available from: https://sid.ir/paper/48494/en

IEEE: Copy

A. NOKHOUDCHI, P. ZAKERI MILANI, H. VALIZADEH, and D. HASSANZADEH, “PERFORMANCE OF POLYMERS IN MICROCAPSULES OF ACETYL SALICYLIC ACID,” PHARMACEUTICAL SCIENCES, vol. -, no. 4, pp. 87–93, 2001, [Online]. Available: https://sid.ir/paper/48494/en

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