QUANTITATIVE FOURIER TRANSFORM-INFRARED (FT-IR) ANALYSIS OF COMPARISON WITH THE (HPLC) METHODOLOGY

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HASANZADEH DAVOUD; MALAEKEH NIKOUEI B.

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Journal: PHARMACEUTICAL SCIENCES Year:2000 | Volume:- | Issue:3 Page(s): 25-32

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Title

QUANTITATIVE FOURIER TRANSFORM-INFRARED (FT-IR) ANALYSIS OF COMPARISON WITH THE (HPLC) METHODOLOGY

Author(s)

HASANZADEH DAVOUD | MALAEKEH NIKOUEI B. | Issue Writer Certificate

Keywords

FOURIER TRANSFORMQ3

INFRARED ( FT-IR)Q3

H2-BLOCKERSQ3

QUANTITATIVEQ3

Abstract

Cimetidine , Ranitidine and Famotidine occur in a number of dosage forms, and the USP monograph methods has listed a HPLC method as the official assay procedure for quality control.The goal of this work was to demonstrate an alternative FT-IR technique with ability to determine the amount of drugs in pharmaceutical dosage forms.In this study the three commercial H2 blockers were QUANTITATIVEly analyzed using FT-IR spectrometer. Methods were used for sample preparation and different wave numbers were investigated .The calibration curves were drawn and the commercial tablets were analyzed accordingly. The selected FT-IR method was compared with the HPLC method of USP .The spectra were studied for the pure drug and the tablets. A sharp peak in which the excipients did not show any absorbance was selected for each drug and the peak height was used as a measure of the drug concentration. The selected peaks were in the wave numbers of 1173.08, 1237.79 and 2168.06 for famotidine, ranitidine and cimetidine respectively. The results showed that in tablets containing 200 mg cimetidine 206.7±2.33 (mg) and 201.05±1.31 (mg) was obtained by FT-IR and HPLC methods, respectively. The similar results were obtained for the tablets containing 150mg Ranitidine, and 40 mg Famotidine. For example 150.04±2.87 (mg) and 151.39±12.70) mg Ranitidine and 40.48 and 40.12 (mg) Famotidine, was obtained by FT-IR and HPLC methods, respectively.It is clear that the standard deviations of the amount of the drug in tablets are similar in FT-IR and HPLC methods.

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APA: Copy

HASANZADEH, DAVOUD, & MALAEKEH NIKOUEI, B.. (2000). QUANTITATIVE FOURIER TRANSFORM-INFRARED (FT-IR) ANALYSIS OF COMPARISON WITH THE (HPLC) METHODOLOGY. PHARMACEUTICAL SCIENCES, -(3), 25-32. SID. https://sid.ir/paper/48519/en

Vancouver: Copy

HASANZADEH DAVOUD, MALAEKEH NIKOUEI B.. QUANTITATIVE FOURIER TRANSFORM-INFRARED (FT-IR) ANALYSIS OF COMPARISON WITH THE (HPLC) METHODOLOGY. PHARMACEUTICAL SCIENCES[Internet]. 2000;-(3):25-32. Available from: https://sid.ir/paper/48519/en

IEEE: Copy

DAVOUD HASANZADEH, and B. MALAEKEH NIKOUEI, “QUANTITATIVE FOURIER TRANSFORM-INFRARED (FT-IR) ANALYSIS OF COMPARISON WITH THE (HPLC) METHODOLOGY,” PHARMACEUTICAL SCIENCES, vol. -, no. 3, pp. 25–32, 2000, [Online]. Available: https://sid.ir/paper/48519/en

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