EFFECT OF HPMC K100M AND CARBOPOL 974P ON FLOATING CHARACTERISTICS AND RELEASE PROFILE OF INDOMETHACIN FROM FLOATING DRUG DELIVERY SYSTEMS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ENAYATIFARD R.; SAEIDI MAJID; AKBARI J.; AMIRI S.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: PHARMACEUTICAL SCIENCES Year:2010 | Volume:15 | Issue:4 Page(s): 339-352

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,135

Download:

Cites:

Information Journal Paper

Title

EFFECT OF HPMC K100M AND CARBOPOL 974P ON FLOATING CHARACTERISTICS AND RELEASE PROFILE OF INDOMETHACIN FROM FLOATING DRUG DELIVERY SYSTEMS

Author(s)

ENAYATIFARD R. | SAEIDI MAJID | AKBARI J. | AMIRI S. | Issue Writer Certificate

Keywords

INDOMETHACINQ2

FLOATINGQ1

HPMC K100MQ1

CARBOPOL 934PQ1

DRUG RELEASEQ2

Abstract

Objectives: FLOATING drug delivery system is one of the novel methods in drug delivery. This study evaluates the relationship and influence of formulation factors such as polymer type, drug: polymer ratio and gas forming agents on DRUG RELEASE and FLOATING properties of matrices containing HPMC K100M and carbopol 974P and INDOMETHACIN as a model drug. Methods: In the present study attempt was made to form INDOMETHACIN FLOATING formulations using HPMC K100M, carbopol 974P, lactose and FLOATING agents in different ratios. Tablets were prepared by direct compression method. The physicochemical properties of tablets prepared were investigated. Rate of DRUG RELEASE was studied using USP II at pH 1.2 and 7.2. For study the release kinetics of INDOMETHACIN from the matrix tablets, the release data were fitted to the zero order, first order, higuchi and pepas equations. Results: The results showed that all the polymers used in this study could slow down the release of INDOMETHACIN from the matrices prepared. Addition of gas generating agent to the formulation containing HPMC alone can modify the FLOATING properties of related matrices. Incorporation of carbopol was found to compromise the FLOATING capacity of related formulations due to the difference in the basic properties of HPMC and Carbopol in water uptake potential. Conclusion: Results showed that the effect of combination of polymers and FLOATING agents on DRUG RELEASE and its kinetic. The use of HPMC K100M and lactose in 1:1 ratio and incorporation of 5% of FLOATING agents can lead to suitable FLOATING formulation of INDOMETHACIN.

Cites

No record.

References

No record.

Cite

APA: Copy

ENAYATIFARD, R., SAEIDI, MAJID, AKBARI, J., & AMIRI, S.. (2010). EFFECT OF HPMC K100M AND CARBOPOL 974P ON FLOATING CHARACTERISTICS AND RELEASE PROFILE OF INDOMETHACIN FROM FLOATING DRUG DELIVERY SYSTEMS. PHARMACEUTICAL SCIENCES, 15(4), 339-352. SID. https://sid.ir/paper/48534/en

Vancouver: Copy

ENAYATIFARD R., SAEIDI MAJID, AKBARI J., AMIRI S.. EFFECT OF HPMC K100M AND CARBOPOL 974P ON FLOATING CHARACTERISTICS AND RELEASE PROFILE OF INDOMETHACIN FROM FLOATING DRUG DELIVERY SYSTEMS. PHARMACEUTICAL SCIENCES[Internet]. 2010;15(4):339-352. Available from: https://sid.ir/paper/48534/en

IEEE: Copy

R. ENAYATIFARD, MAJID SAEIDI, J. AKBARI, and S. AMIRI, “EFFECT OF HPMC K100M AND CARBOPOL 974P ON FLOATING CHARACTERISTICS AND RELEASE PROFILE OF INDOMETHACIN FROM FLOATING DRUG DELIVERY SYSTEMS,” PHARMACEUTICAL SCIENCES, vol. 15, no. 4, pp. 339–352, 2010, [Online]. Available: https://sid.ir/paper/48534/en

Related Journal Papers