THE FORMULATION OF CAPTOPRIL SUSTAINED RELEASE TABLETS

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DABAGH M.A.; MOEYIN M.

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Journal: PHARMACEUTICAL SCIENCES Year:2002 | Volume:- | Issue:1 Page(s): 21-32

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Title

THE FORMULATION OF CAPTOPRIL SUSTAINED RELEASE TABLETS

Author(s)

DABAGH M.A. | MOEYIN M. | Issue Writer Certificate

Keywords

CAPTOPRILQ3

HYDRODYNAMICALLY BALANCED SYSTEMQ3

FLOATING AND BIOADHESIVEQ3

MATRIX TABLETSQ3

Abstract

CAPTOPRIL, an angiotensin-converting enzyme inhibitor (ACEI), has an excellent clinical effectiveness in the treatment of hypertension and congestive heart failure (CHF). Up to now various attempts have been made to make a sustained-release drug delivery system of CAPTOPRIL. One of these systems is known as "Hydrodynamically balanced system". Such a system is useful for drugs well absorbed in the proximal gastrointestinal tract or for drugs that degrade in the intestinal fluid (like CAPTOPRIL). The aim of this study was: designing, formulation and in-vitro releasing pattern evaluation of FLOATING AND BIOADHESIVE sustained-release CAPTOPRIL MATRIX TABLETS, especially by using yellow bees wax in the formulations. Investigation of stability of CAPTOPRIL solutions with various concentrations indicated that these solutions are stable in the conditions of dissolution test (HCI 0.1 N, at 37±0.5 °c) regardless of air and light, and there is no need to add an antioxidant agent to the dissolution medium. Among different tablet formulations which were made, the formulation known as 03 (Containing: 30% yellow bees wax, 30% HPMC, 16% carbopol and 5% magnesium stearate) showed a suitable releasing pattern and a high production efficiency During dissolution tests these tablets remained floating. In the progress of this investigation it was proved that there is a direct relation between tablets hardness and granule production efficiency with P/W ratio (powders which used in granulation (P) to wax content of production (W). On the other hand it was indicated that there is a reverse relation between buoyancy time of tablets and their hardness.

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APA: Copy

DABAGH, M.A., & MOEYIN, M.. (2002). THE FORMULATION OF CAPTOPRIL SUSTAINED RELEASE TABLETS. PHARMACEUTICAL SCIENCES, -(1), 21-32. SID. https://sid.ir/paper/48604/en

Vancouver: Copy

DABAGH M.A., MOEYIN M.. THE FORMULATION OF CAPTOPRIL SUSTAINED RELEASE TABLETS. PHARMACEUTICAL SCIENCES[Internet]. 2002;-(1):21-32. Available from: https://sid.ir/paper/48604/en

IEEE: Copy

M.A. DABAGH, and M. MOEYIN, “THE FORMULATION OF CAPTOPRIL SUSTAINED RELEASE TABLETS,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 21–32, 2002, [Online]. Available: https://sid.ir/paper/48604/en

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