PREPARATION AND EVALUATION OF CARBAMAZEPINE-SUPERDISINTEGRANTS AGGLOMERATES BY SPHERICAL CRYSTALLIZATION TECHNIQUE

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MAGHSOUDI MARYAM; TAJALLI BAKHSH A.A.S.

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Journal: PHARMACEUTICAL SCIENCES Year:2010 | Volume:16 | Issue:1 Page(s): 1-10

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Title

PREPARATION AND EVALUATION OF CARBAMAZEPINE-SUPERDISINTEGRANTS AGGLOMERATES BY SPHERICAL CRYSTALLIZATION TECHNIQUE

Author(s)

MAGHSOUDI MARYAM | TAJALLI BAKHSH A.A.S. | Issue Writer Certificate

Keywords

SPHERICAL CRYSTALLIZATIONQ1

DISSOLUTION RATEQ2

DRUG-EXCIPIENT INTERACTIONQ1

SUPERDISINTEGRANTQ1

CARBAMAZEPINEQ2

Abstract

Objective: The purpose of this study was to prepare and evaluate CARBAMAZEPINE (CBZ)-superdisintegrants agglomerates by SPHERICAL CRYSTALLIZATION technique.Methods: The process involved recrystallization of CBZ and its simultaneous agglomeration with disintegrants: sodium starch glycolate (SSG) or croscarmellose sodium (CCS). An ethanol, isopropyl acetate, water system was used, where they acted as solvent, bridging liquid and non-solvent respectively. The agglomerates were characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (XRPD), FTIR and Scanning electron microscopy and were evaluated for micromeritic properties, disintegration time and drug release.Results: In comparison to conventional drug crystals, the agglomerates depicted significantly improved micromeritic properties and their DISSOLUTION RATEs were enhanced. Although CBZ-CCS agglomerates showed better disintegration time than CBZ-SSG agglomerates, CCS had lower effect on DISSOLUTION RATE, probably due to possible charge interactions with drug.Conclusion: SPHERICAL CRYSTALLIZATION is an efficient and simple technique, which is useful for preparing drug-superdisintegrants agglomerates to improve the micromeritic properties and the DISSOLUTION RATEs.

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APA: Copy

MAGHSOUDI, MARYAM, & TAJALLI BAKHSH, A.A.S.. (2010). PREPARATION AND EVALUATION OF CARBAMAZEPINE-SUPERDISINTEGRANTS AGGLOMERATES BY SPHERICAL CRYSTALLIZATION TECHNIQUE. PHARMACEUTICAL SCIENCES, 16(1), 1-10. SID. https://sid.ir/paper/48646/en

Vancouver: Copy

MAGHSOUDI MARYAM, TAJALLI BAKHSH A.A.S.. PREPARATION AND EVALUATION OF CARBAMAZEPINE-SUPERDISINTEGRANTS AGGLOMERATES BY SPHERICAL CRYSTALLIZATION TECHNIQUE. PHARMACEUTICAL SCIENCES[Internet]. 2010;16(1):1-10. Available from: https://sid.ir/paper/48646/en

IEEE: Copy

MARYAM MAGHSOUDI, and A.A.S. TAJALLI BAKHSH, “PREPARATION AND EVALUATION OF CARBAMAZEPINE-SUPERDISINTEGRANTS AGGLOMERATES BY SPHERICAL CRYSTALLIZATION TECHNIQUE,” PHARMACEUTICAL SCIENCES, vol. 16, no. 1, pp. 1–10, 2010, [Online]. Available: https://sid.ir/paper/48646/en

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