THE EFFECT OF POLYMER TYPE AND CONCENTRATION ON THE RELEASE OF ATENOLOL FROM MATRICES

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LOTFIPOOR F.; NOKHOUDCHI A.; SAEIDI M.; SIAHI M.R.

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Journal: PHARMACEUTICAL SCIENCES Year:2003 | Volume:- | Issue:2 Page(s): 75-84

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Title

THE EFFECT OF POLYMER TYPE AND CONCENTRATION ON THE RELEASE OF ATENOLOL FROM MATRICES

Author(s)

LOTFIPOOR F. | NOKHOUDCHI A. | SAEIDI M. | SIAHI M.R. | Issue Writer Certificate

Keywords

ATENOLOLQ3

RELEASE RATEQ3

POLYMER TYPEQ3

POLYMER CONCENTRATIONQ3

Abstract

Hydrophilic and Hydrophobic polymers are widely used excipients to control the release of active ingredients from matrices. In this research the effect of various parameter (Type of polymers and their concentrations). On the RELEASE RATE of ATENOLOL were investigated. Four polymers namely Eudragit RSPO, HPMC K4M NaCMC and EC were used. The results showed that an increase in the Concentration of HPMC and EC in the matrices resulted in a reduetion in the RELEASE RATE of ATENOLOL. As the amount of Eudragit was increased in HPMC matrices the RELEASE RATE of ATENOLOL was not significantly changed (HPMC: Eudragit 3:1). When the ratio of HPMC: Eudragit was 1:1 the RELEASE RATE of ATENOLOL Significantly increased. The results showed that the RELEASE RATE of ATENOLOL from NaCMC matrices is similar to HPMC matrices at pH 1.2, but the RELEASE RATE at pH 6.8 significantly increased. It can be concluded that the type and concentration of polymers are able to control the RELEASE RATE of ATENOLOL from matrices formulations.

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APA: Copy

LOTFIPOOR, F., NOKHOUDCHI, A., SAEIDI, M., & SIAHI, M.R.. (2003). THE EFFECT OF POLYMER TYPE AND CONCENTRATION ON THE RELEASE OF ATENOLOL FROM MATRICES. PHARMACEUTICAL SCIENCES, -(2), 75-84. SID. https://sid.ir/paper/48647/en

Vancouver: Copy

LOTFIPOOR F., NOKHOUDCHI A., SAEIDI M., SIAHI M.R.. THE EFFECT OF POLYMER TYPE AND CONCENTRATION ON THE RELEASE OF ATENOLOL FROM MATRICES. PHARMACEUTICAL SCIENCES[Internet]. 2003;-(2):75-84. Available from: https://sid.ir/paper/48647/en

IEEE: Copy

F. LOTFIPOOR, A. NOKHOUDCHI, M. SAEIDI, and M.R. SIAHI, “THE EFFECT OF POLYMER TYPE AND CONCENTRATION ON THE RELEASE OF ATENOLOL FROM MATRICES,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 75–84, 2003, [Online]. Available: https://sid.ir/paper/48647/en

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